Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease

Alzheimer's disease (AD), a heterogeneous neurodegenerative disorder, is the most common cause of dementia accounting for an estimated 60–80% of cases. The pathogenesis of AD remains unclear, and no curative treatment is available so far. Increasing evidence has revealed a vital role of non-cod...

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Autores principales: Lan, Zhen, Chen, Yanting, Jin, Jiali, Xu, Yun, Zhu, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Molecular Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795976/
https://www.ncbi.nlm.nih.gov/pubmed/35095418
http://dx.doi.org/10.3389/fnmol.2021.821002
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author Lan, Zhen
Chen, Yanting
Jin, Jiali
Xu, Yun
Zhu, Xiaolei
author_facet Lan, Zhen
Chen, Yanting
Jin, Jiali
Xu, Yun
Zhu, Xiaolei
author_sort Lan, Zhen
collection PubMed
description Alzheimer's disease (AD), a heterogeneous neurodegenerative disorder, is the most common cause of dementia accounting for an estimated 60–80% of cases. The pathogenesis of AD remains unclear, and no curative treatment is available so far. Increasing evidence has revealed a vital role of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), in AD. LncRNAs contribute to the pathogenesis of AD via modulating amyloid production, Tau hyperphosphorylation, mitochondrial dysfunction, oxidative stress, synaptic impairment and neuroinflammation. This review describes the biological functions and mechanisms of lncRNAs in AD, indicating that lncRNAs may provide potential therapeutic targets for the diagnosis and treatment of AD.
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spelling pubmed-87959762022-01-29 Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease Lan, Zhen Chen, Yanting Jin, Jiali Xu, Yun Zhu, Xiaolei Front Mol Neurosci Molecular Neuroscience Alzheimer's disease (AD), a heterogeneous neurodegenerative disorder, is the most common cause of dementia accounting for an estimated 60–80% of cases. The pathogenesis of AD remains unclear, and no curative treatment is available so far. Increasing evidence has revealed a vital role of non-coding RNAs (ncRNAs), especially long non-coding RNAs (lncRNAs), in AD. LncRNAs contribute to the pathogenesis of AD via modulating amyloid production, Tau hyperphosphorylation, mitochondrial dysfunction, oxidative stress, synaptic impairment and neuroinflammation. This review describes the biological functions and mechanisms of lncRNAs in AD, indicating that lncRNAs may provide potential therapeutic targets for the diagnosis and treatment of AD. Frontiers Media S.A. 2022-01-14 /pmc/articles/PMC8795976/ /pubmed/35095418 http://dx.doi.org/10.3389/fnmol.2021.821002 Text en Copyright © 2022 Lan, Chen, Jin, Xu and Zhu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Molecular Neuroscience
Lan, Zhen
Chen, Yanting
Jin, Jiali
Xu, Yun
Zhu, Xiaolei
Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease
title Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease
title_full Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease
title_fullStr Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease
title_full_unstemmed Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease
title_short Long Non-coding RNA: Insight Into Mechanisms of Alzheimer's Disease
title_sort long non-coding rna: insight into mechanisms of alzheimer's disease
topic Molecular Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8795976/
https://www.ncbi.nlm.nih.gov/pubmed/35095418
http://dx.doi.org/10.3389/fnmol.2021.821002
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