Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus

The objective of the present study was to identify the association of the TNF-α- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms with the risk of development of type 2 diabetes mellitus (T2DM). Methods: A total of 160 volunteers were studied: 108 with T2DM and 52 participants as control, w...

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Autores principales: Trapali, Maria, Houhoula, Dimitra, Batrinou, Anthimia, Kanellou, Anastasia, Strati, Irini F., Siatelis, Argyris, Halvatsiotis, Panagiotis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796026/
https://www.ncbi.nlm.nih.gov/pubmed/35052401
http://dx.doi.org/10.3390/genes13010059
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author Trapali, Maria
Houhoula, Dimitra
Batrinou, Anthimia
Kanellou, Anastasia
Strati, Irini F.
Siatelis, Argyris
Halvatsiotis, Panagiotis
author_facet Trapali, Maria
Houhoula, Dimitra
Batrinou, Anthimia
Kanellou, Anastasia
Strati, Irini F.
Siatelis, Argyris
Halvatsiotis, Panagiotis
author_sort Trapali, Maria
collection PubMed
description The objective of the present study was to identify the association of the TNF-α- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms with the risk of development of type 2 diabetes mellitus (T2DM). Methods: A total of 160 volunteers were studied: 108 with T2DM and 52 participants as control, who served as the control group. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for the genomic region of TNF-α- 308G/A and LEPR Gln223Arg were carried out. Results: The frequency of LEPR Gln223Arg genotypes in T2DM and control groups showed significant differences in the distribution of genotypes (p < 0.05). The frequency also of TNF-α- 308G/A genotypes in T2DM and control subjects showed significant differences in the distribution of genotypes (p < 0.05). Conclusion: Our results indicate that there are significant differences in the distribution of genotypes and alleles between the individuals with T2DM and control subjects (p < 0.05).
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spelling pubmed-87960262022-01-29 Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus Trapali, Maria Houhoula, Dimitra Batrinou, Anthimia Kanellou, Anastasia Strati, Irini F. Siatelis, Argyris Halvatsiotis, Panagiotis Genes (Basel) Article The objective of the present study was to identify the association of the TNF-α- 308G/A and leptin receptor (LEPR) Gln223Arg polymorphisms with the risk of development of type 2 diabetes mellitus (T2DM). Methods: A total of 160 volunteers were studied: 108 with T2DM and 52 participants as control, who served as the control group. Polymerase chain reaction–restriction fragment length polymorphism (PCR-RFLP) for the genomic region of TNF-α- 308G/A and LEPR Gln223Arg were carried out. Results: The frequency of LEPR Gln223Arg genotypes in T2DM and control groups showed significant differences in the distribution of genotypes (p < 0.05). The frequency also of TNF-α- 308G/A genotypes in T2DM and control subjects showed significant differences in the distribution of genotypes (p < 0.05). Conclusion: Our results indicate that there are significant differences in the distribution of genotypes and alleles between the individuals with T2DM and control subjects (p < 0.05). MDPI 2021-12-27 /pmc/articles/PMC8796026/ /pubmed/35052401 http://dx.doi.org/10.3390/genes13010059 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Trapali, Maria
Houhoula, Dimitra
Batrinou, Anthimia
Kanellou, Anastasia
Strati, Irini F.
Siatelis, Argyris
Halvatsiotis, Panagiotis
Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus
title Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus
title_full Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus
title_fullStr Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus
title_full_unstemmed Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus
title_short Association of TNF-α 308G/A and LEPR Gln223Arg Polymorphisms with the Risk of Type 2 Diabetes Mellitus
title_sort association of tnf-α 308g/a and lepr gln223arg polymorphisms with the risk of type 2 diabetes mellitus
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796026/
https://www.ncbi.nlm.nih.gov/pubmed/35052401
http://dx.doi.org/10.3390/genes13010059
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