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Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?

Microglia are the primary immune cells in CNS. Recent work shows that microglia are also essential for proper brain development through synaptic pruning and remodeling during early life development. But the question of whether and how microglia regulate synaptic connectivity in the adult brain remai...

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Detalles Bibliográficos
Autores principales: Liu, Yong-Jun, Green, Kim N, Holmes, Todd C, Xu, Xiangmin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796061/
https://www.ncbi.nlm.nih.gov/pubmed/35098130
http://dx.doi.org/10.1177/26331055211071124
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author Liu, Yong-Jun
Green, Kim N
Holmes, Todd C
Xu, Xiangmin
author_facet Liu, Yong-Jun
Green, Kim N
Holmes, Todd C
Xu, Xiangmin
author_sort Liu, Yong-Jun
collection PubMed
description Microglia are the primary immune cells in CNS. Recent work shows that microglia are also essential for proper brain development through synaptic pruning and remodeling during early life development. But the question of whether and how microglia regulate synaptic connectivity in the adult brain remains open. Our recently published study provides new insights into the functional roles of microglia in the adult mouse brain. We find that chronic depletion of microglia via CSF1R inhibitors in the visual cortex in adult mice induces a dramatic increase in perineuronal nets, and enhances neural activities of both excitatory neurons and parvalbumin interneurons. These findings highlight new potential therapeutic avenues to enhance adult neural plasticity by manipulating microglia.
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spelling pubmed-87960612022-01-29 Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain? Liu, Yong-Jun Green, Kim N Holmes, Todd C Xu, Xiangmin Neurosci Insights Commentary Microglia are the primary immune cells in CNS. Recent work shows that microglia are also essential for proper brain development through synaptic pruning and remodeling during early life development. But the question of whether and how microglia regulate synaptic connectivity in the adult brain remains open. Our recently published study provides new insights into the functional roles of microglia in the adult mouse brain. We find that chronic depletion of microglia via CSF1R inhibitors in the visual cortex in adult mice induces a dramatic increase in perineuronal nets, and enhances neural activities of both excitatory neurons and parvalbumin interneurons. These findings highlight new potential therapeutic avenues to enhance adult neural plasticity by manipulating microglia. SAGE Publications 2022-01-24 /pmc/articles/PMC8796061/ /pubmed/35098130 http://dx.doi.org/10.1177/26331055211071124 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by-nc/4.0/This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Commentary
Liu, Yong-Jun
Green, Kim N
Holmes, Todd C
Xu, Xiangmin
Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
title Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
title_full Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
title_fullStr Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
title_full_unstemmed Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
title_short Commentary: How Do Microglia Regulate Neural Circuit Connectivity and Activity in the Adult Brain?
title_sort commentary: how do microglia regulate neural circuit connectivity and activity in the adult brain?
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796061/
https://www.ncbi.nlm.nih.gov/pubmed/35098130
http://dx.doi.org/10.1177/26331055211071124
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