Predictive Value of CHA(2)DS(2) -VASc-HSF Score for Severity of Acute Coronary Syndrome

CHADS(2) and CHA(2)DS(2)-VASc scores have been used to assess the prognostic risk of thromboembolism in non-valvular atrial fibrillation patients. Recent studies have shown the utility of CHADS(2) and CHA(2)DS(2)-VASc scores for evaluating the severity of coronary artery disease (CAD). The newly defined CHA(2)DS(2)-VASc-HSF score evaluates atherosclerosis and is associated with CAD severity. This study investigated the association between the CHA(2)DS(2)-VASc-HSF score and acute coronary syndrome (ACS) severity as assessed by the Gensini score and the number of vessels. Furthermore, this study also compared the diagnostic value of the CHADS(2), CHA2 DS2-VASc, and CHA(2)DS(2)-VASc-HSF score for ACS. A total of 2367 eligible inpatients (ACS group [n = 2030]; non-CAD group [n = 337]) were consecutively enrolled in this study. Receiver operating characteristic curve diagnostic tests and logistic regression models were used to analyze the risk factors for ACS. The CHADS(2), CHA(2)DS(2)-VASc, and CHA(2)DS(2)-VASc-HSF scores were significantly higher in the ACS group than those in the control group. After adjusting for numerous traditional CAD risk factors, an increased CHA(2)DS(2)-VASc-HSF score was found to be an independent risk factor for patients with ACS (odds ratio 1.401, 95% confidence interval 1.044, −1.879; P < 0.05). A newly diagnosed CHA(2)DS(2)-VASc-HSF score predicts the severity of ACS.