SCP4-STK35/PDIK1L complex is a dual phospho-catalytic signaling dependency in acute myeloid leukemia

Acute myeloid leukemia (AML) cells rely on phospho-signaling pathways to gain unlimited proliferation potential. Here, we use domain-focused CRISPR screening and identify the nuclear phosphatase SCP4 as a dependency in AML, yet this enzyme is dispensable in normal hematopoietic progenitor cells. Usi...

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Detalles Bibliográficos
Autores principales: Polyanskaya, Sofya A., Moreno, Rosamaria Y., Lu, Bin, Feng, Ruopeng, Yao, Yu, Irani, Seema, Klingbeil, Olaf, Yang, Zhaolin, Wei, Yiliang, Demerdash, Osama E., Benjamin, Lukas A., Weiss, Mitchell J., Zhang, Yan Jessie, Vakoc, Christopher R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796272/
https://www.ncbi.nlm.nih.gov/pubmed/35021089
http://dx.doi.org/10.1016/j.celrep.2021.110233

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