Cargando…
Benefits and adverse events of melatonin use in the elderly (Review)
Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal p...
Autores principales: | , , , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
D.A. Spandidos
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796282/ https://www.ncbi.nlm.nih.gov/pubmed/35126722 http://dx.doi.org/10.3892/etm.2022.11142 |
_version_ | 1784641270792060928 |
---|---|
author | Anghel, Lucreția Baroiu, Liliana Popazu, Corina Rișcă Pătraș, Diana Fotea, Silvia Nechifor, Alexandru Ciubara, Anamaria Nechita, Luiza Mușat, Carmina Liana Stefanopol, Ioana Anca Tatu, Alin Laurențiu Ciubara, Alexandru Bogdan |
author_facet | Anghel, Lucreția Baroiu, Liliana Popazu, Corina Rișcă Pătraș, Diana Fotea, Silvia Nechifor, Alexandru Ciubara, Anamaria Nechita, Luiza Mușat, Carmina Liana Stefanopol, Ioana Anca Tatu, Alin Laurențiu Ciubara, Alexandru Bogdan |
author_sort | Anghel, Lucreția |
collection | PubMed |
description | Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal pathways of transmission to the pineal gland. A significant decrease in melatonin synthesis has been reported in various disorders and diseases, including cardiovascular diseases, metabolic disorders (particularly diabetes type 2), cancer and endocrine diseases. In addition to the fact, that melatonin is a sleep inducer, it also exerts cytoprotective properties as an antioxidant and free radical scavenger. The therapeutic role of melatonin has been demonstrated in sleep disorders, eye damage and cardiovascular disease. The association between melatonin and β-blockers has had a positive impact on sleep disorders in clinical trials. Previous studies have reported the anti-inflammatory effect of melatonin by adjusting levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1β and tumor necrosis factor-α. Melatonin treatment has been demonstrated to decrease IL-6 and IL-10 expression levels and efficiently attenuate T-cell proliferation. Currently, there is an inconsistency of scientific data regarding the lowest optimal dose and safety of melatonin for long-term use. The aim of the present review was to summarize the evidence on the role of melatonin in various clinical conditions and highlight the future research in this area. |
format | Online Article Text |
id | pubmed-8796282 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | D.A. Spandidos |
record_format | MEDLINE/PubMed |
spelling | pubmed-87962822022-02-03 Benefits and adverse events of melatonin use in the elderly (Review) Anghel, Lucreția Baroiu, Liliana Popazu, Corina Rișcă Pătraș, Diana Fotea, Silvia Nechifor, Alexandru Ciubara, Anamaria Nechita, Luiza Mușat, Carmina Liana Stefanopol, Ioana Anca Tatu, Alin Laurențiu Ciubara, Alexandru Bogdan Exp Ther Med Review Melatonin is a hormone secreted by the pineal gland in accordance with the circadian rhythm when the light level decreases. Reduction of melatonin secretion with age may be associated with physiological aging in neurodegenerative diseases by affecting the suprachiasmatic nucleus or of the neuronal pathways of transmission to the pineal gland. A significant decrease in melatonin synthesis has been reported in various disorders and diseases, including cardiovascular diseases, metabolic disorders (particularly diabetes type 2), cancer and endocrine diseases. In addition to the fact, that melatonin is a sleep inducer, it also exerts cytoprotective properties as an antioxidant and free radical scavenger. The therapeutic role of melatonin has been demonstrated in sleep disorders, eye damage and cardiovascular disease. The association between melatonin and β-blockers has had a positive impact on sleep disorders in clinical trials. Previous studies have reported the anti-inflammatory effect of melatonin by adjusting levels of pro-inflammatory cytokines, including interleukin (IL)-6, IL-1β and tumor necrosis factor-α. Melatonin treatment has been demonstrated to decrease IL-6 and IL-10 expression levels and efficiently attenuate T-cell proliferation. Currently, there is an inconsistency of scientific data regarding the lowest optimal dose and safety of melatonin for long-term use. The aim of the present review was to summarize the evidence on the role of melatonin in various clinical conditions and highlight the future research in this area. D.A. Spandidos 2022-03 2022-01-14 /pmc/articles/PMC8796282/ /pubmed/35126722 http://dx.doi.org/10.3892/etm.2022.11142 Text en Copyright: © Anghel et al. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License (https://creativecommons.org/licenses/by-nc-nd/4.0/) , which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made. |
spellingShingle | Review Anghel, Lucreția Baroiu, Liliana Popazu, Corina Rișcă Pătraș, Diana Fotea, Silvia Nechifor, Alexandru Ciubara, Anamaria Nechita, Luiza Mușat, Carmina Liana Stefanopol, Ioana Anca Tatu, Alin Laurențiu Ciubara, Alexandru Bogdan Benefits and adverse events of melatonin use in the elderly (Review) |
title | Benefits and adverse events of melatonin use in the elderly (Review) |
title_full | Benefits and adverse events of melatonin use in the elderly (Review) |
title_fullStr | Benefits and adverse events of melatonin use in the elderly (Review) |
title_full_unstemmed | Benefits and adverse events of melatonin use in the elderly (Review) |
title_short | Benefits and adverse events of melatonin use in the elderly (Review) |
title_sort | benefits and adverse events of melatonin use in the elderly (review) |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796282/ https://www.ncbi.nlm.nih.gov/pubmed/35126722 http://dx.doi.org/10.3892/etm.2022.11142 |
work_keys_str_mv | AT anghellucretia benefitsandadverseeventsofmelatoninuseintheelderlyreview AT baroiuliliana benefitsandadverseeventsofmelatoninuseintheelderlyreview AT popazucorinarisca benefitsandadverseeventsofmelatoninuseintheelderlyreview AT patrasdiana benefitsandadverseeventsofmelatoninuseintheelderlyreview AT foteasilvia benefitsandadverseeventsofmelatoninuseintheelderlyreview AT nechiforalexandru benefitsandadverseeventsofmelatoninuseintheelderlyreview AT ciubaraanamaria benefitsandadverseeventsofmelatoninuseintheelderlyreview AT nechitaluiza benefitsandadverseeventsofmelatoninuseintheelderlyreview AT musatcarminaliana benefitsandadverseeventsofmelatoninuseintheelderlyreview AT stefanopolioanaanca benefitsandadverseeventsofmelatoninuseintheelderlyreview AT tatualinlaurentiu benefitsandadverseeventsofmelatoninuseintheelderlyreview AT ciubaraalexandrubogdan benefitsandadverseeventsofmelatoninuseintheelderlyreview |