Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022

Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3...

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Autores principales: Eggink, Dirk, Andeweg, Stijn P, Vennema, Harry, van Maarseveen, Noortje, Vermaas, Klaas, Vlaemynck, Boris, Schepers, Raf, van Gageldonk-Lafeber, Arianne B, van den Hof, Susan, Reusken, Chantal BEM, Knol, Mirjam J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: European Centre for Disease Prevention and Control (ECDC) 2022
Materias:
Rapid Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796294/
https://www.ncbi.nlm.nih.gov/pubmed/35086609
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.4.2101196
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author Eggink, Dirk
Andeweg, Stijn P
Vennema, Harry
van Maarseveen, Noortje
Vermaas, Klaas
Vlaemynck, Boris
Schepers, Raf
van Gageldonk-Lafeber, Arianne B
van den Hof, Susan
Reusken, Chantal BEM
Knol, Mirjam J
author_facet Eggink, Dirk
Andeweg, Stijn P
Vennema, Harry
van Maarseveen, Noortje
Vermaas, Klaas
Vlaemynck, Boris
Schepers, Raf
van Gageldonk-Lafeber, Arianne B
van den Hof, Susan
Reusken, Chantal BEM
Knol, Mirjam J
author_sort Eggink, Dirk
collection PubMed
description Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant.
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spelling pubmed-87962942022-02-22 Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022 Eggink, Dirk Andeweg, Stijn P Vennema, Harry van Maarseveen, Noortje Vermaas, Klaas Vlaemynck, Boris Schepers, Raf van Gageldonk-Lafeber, Arianne B van den Hof, Susan Reusken, Chantal BEM Knol, Mirjam J Euro Surveill Rapid Communication Infections with the Omicron SARS-CoV-2 variant are rapidly increasing worldwide. Among 174,349 SARS-CoV-2-infected individuals (≥ 12 years), we observed an increased risk of S gene target failure, predictive of the Omicron variant, in vaccinated (odds ratio (OR): 3.6; 95% confidence interval (CI): 3.4–3.7) and previously infected individuals (OR: 4.2; 95% CI: 3.8–4.7) compared with infected naïve individuals. This suggests vaccine- or infection-induced immunity against SARS-CoV-2 infections is less effective against the Omicron than the Delta variant. European Centre for Disease Prevention and Control (ECDC) 2022-01-27 /pmc/articles/PMC8796294/ /pubmed/35086609 http://dx.doi.org/10.2807/1560-7917.ES.2022.27.4.2101196 Text en This article is copyright of the authors or their affiliated institutions, 2022. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution (CC BY 4.0) Licence. You may share and adapt the material, but must give appropriate credit to the source, provide a link to the licence, and indicate if changes were made.
spellingShingle Rapid Communication
Eggink, Dirk
Andeweg, Stijn P
Vennema, Harry
van Maarseveen, Noortje
Vermaas, Klaas
Vlaemynck, Boris
Schepers, Raf
van Gageldonk-Lafeber, Arianne B
van den Hof, Susan
Reusken, Chantal BEM
Knol, Mirjam J
Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
title Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
title_full Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
title_fullStr Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
title_full_unstemmed Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
title_short Increased risk of infection with SARS-CoV-2 Omicron BA.1 compared with Delta in vaccinated and previously infected individuals, the Netherlands, 22 November 2021 to 19 January 2022
title_sort increased risk of infection with sars-cov-2 omicron ba.1 compared with delta in vaccinated and previously infected individuals, the netherlands, 22 november 2021 to 19 january 2022
topic Rapid Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796294/
https://www.ncbi.nlm.nih.gov/pubmed/35086609
http://dx.doi.org/10.2807/1560-7917.ES.2022.27.4.2101196
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