Variant Library Annotation Tool (VaLiAnT): an oligonucleotide library design and annotation tool for saturation genome editing and other deep mutational scanning experiments

MOTIVATION: CRISPR/Cas9-based technology allows for the functional analysis of genetic variants at single nucleotide resolution whilst maintaining genomic context. This approach, known as saturation genome editing (SGE), a form of deep mutational scanning, systematically alters each position in a ta...

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Detalles Bibliográficos
Autores principales: Barbon, Luca, Offord, Victoria, Radford, Elizabeth J, Butler, Adam P, Gerety, Sebastian S, Adams, David J, Tan, Hong Kee, Waters, Andrew J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2021
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796380/
https://www.ncbi.nlm.nih.gov/pubmed/34791067
http://dx.doi.org/10.1093/bioinformatics/btab776

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