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A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas

BACKGROUND: Crohn’s disease (CD)-related rectovaginal fistulas (RVFs) and anovaginal fistulas (AVFs) are rare, debilitating conditions that present a substantial disease and treatment burden for women. This systematic literature review (SLR) assessed the burden of Crohn’s-related RVF and AVF, summar...

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Autores principales: Iglay, Kristy, Bennett, Dimitri, Kappelman, Michael D., Thai, Sydney, Aldridge, Molly, Karki, Chitra, Cook, Suzanne F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796404/
https://www.ncbi.nlm.nih.gov/pubmed/35090384
http://dx.doi.org/10.1186/s12876-021-02079-8
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author Iglay, Kristy
Bennett, Dimitri
Kappelman, Michael D.
Thai, Sydney
Aldridge, Molly
Karki, Chitra
Cook, Suzanne F.
author_facet Iglay, Kristy
Bennett, Dimitri
Kappelman, Michael D.
Thai, Sydney
Aldridge, Molly
Karki, Chitra
Cook, Suzanne F.
author_sort Iglay, Kristy
collection PubMed
description BACKGROUND: Crohn’s disease (CD)-related rectovaginal fistulas (RVFs) and anovaginal fistulas (AVFs) are rare, debilitating conditions that present a substantial disease and treatment burden for women. This systematic literature review (SLR) assessed the burden of Crohn’s-related RVF and AVF, summarizing evidence from observational studies and highlighting knowledge gaps. METHODS: This SLR identified articles in PubMed and Embase that provide data and insight into the patient experience and disease burden of Crohn’s-related RVF and AVF. Two trained reviewers used pre-specified eligibility criteria to identify studies for inclusion and evaluate risk of bias using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool for observational studies. RESULTS: Of the 582 records identified, 316 full-text articles were assessed, and 16 studies met a priori eligibility criteria and were included. Few epidemiology studies were identified, with one study estimating the prevalence of RVF to be 2.3% in females with Crohn’s disease. Seven of 12 treatment pattern studies reported that patients had or required additional procedures before and/or after the intervention of interest, demonstrating a substantial treatment burden. Seven of 11 studies assessing clinical outcomes reported fistula healing rates between 50 and 75%, with varying estimates based on population and intervention. CONCLUSIONS: This SLR reports the high disease and treatment burden of Crohn’s-related RVF and AVF and identifies multiple evidence gaps in this field. The literature lacks robust, generalizable data, and demonstrates a compelling need for substantial, novel research into these rare and debilitating sequelae of CD. Registration The PROSPERO registration number for the protocol for this systematic literature review is CRD42020177732. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-021-02079-8.
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spelling pubmed-87964042022-02-03 A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas Iglay, Kristy Bennett, Dimitri Kappelman, Michael D. Thai, Sydney Aldridge, Molly Karki, Chitra Cook, Suzanne F. BMC Gastroenterol Research Article BACKGROUND: Crohn’s disease (CD)-related rectovaginal fistulas (RVFs) and anovaginal fistulas (AVFs) are rare, debilitating conditions that present a substantial disease and treatment burden for women. This systematic literature review (SLR) assessed the burden of Crohn’s-related RVF and AVF, summarizing evidence from observational studies and highlighting knowledge gaps. METHODS: This SLR identified articles in PubMed and Embase that provide data and insight into the patient experience and disease burden of Crohn’s-related RVF and AVF. Two trained reviewers used pre-specified eligibility criteria to identify studies for inclusion and evaluate risk of bias using the Risk Of Bias In Non-randomized Studies of Interventions (ROBINS-I) tool for observational studies. RESULTS: Of the 582 records identified, 316 full-text articles were assessed, and 16 studies met a priori eligibility criteria and were included. Few epidemiology studies were identified, with one study estimating the prevalence of RVF to be 2.3% in females with Crohn’s disease. Seven of 12 treatment pattern studies reported that patients had or required additional procedures before and/or after the intervention of interest, demonstrating a substantial treatment burden. Seven of 11 studies assessing clinical outcomes reported fistula healing rates between 50 and 75%, with varying estimates based on population and intervention. CONCLUSIONS: This SLR reports the high disease and treatment burden of Crohn’s-related RVF and AVF and identifies multiple evidence gaps in this field. The literature lacks robust, generalizable data, and demonstrates a compelling need for substantial, novel research into these rare and debilitating sequelae of CD. Registration The PROSPERO registration number for the protocol for this systematic literature review is CRD42020177732. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12876-021-02079-8. BioMed Central 2022-01-28 /pmc/articles/PMC8796404/ /pubmed/35090384 http://dx.doi.org/10.1186/s12876-021-02079-8 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Iglay, Kristy
Bennett, Dimitri
Kappelman, Michael D.
Thai, Sydney
Aldridge, Molly
Karki, Chitra
Cook, Suzanne F.
A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas
title A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas
title_full A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas
title_fullStr A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas
title_full_unstemmed A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas
title_short A systematic review of the patient burden of Crohn’s disease-related rectovaginal and anovaginal fistulas
title_sort systematic review of the patient burden of crohn’s disease-related rectovaginal and anovaginal fistulas
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796404/
https://www.ncbi.nlm.nih.gov/pubmed/35090384
http://dx.doi.org/10.1186/s12876-021-02079-8
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