Acute minocycline administration reduces brain injury and improves long-term functional outcomes after delayed hypoxemia following traumatic brain injury

Clinical trials of therapeutics for traumatic brain injury (TBI) demonstrating preclinical efficacy for TBI have failed to replicate these results in humans, in part due to the absence of clinically feasible therapeutic windows for administration. Minocycline, an inhibitor of microglial activation,...

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Detalles Bibliográficos
Autores principales: Celorrio, Marta, Shumilov, Kirill, Payne, Camryn, Vadivelu, Sangeetha, Friess, Stuart H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796448/
https://www.ncbi.nlm.nih.gov/pubmed/35090569
http://dx.doi.org/10.1186/s40478-022-01310-1

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