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The expression and survival significance of sodium glucose transporters in pancreatic cancer

BACKGROUND: Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with prognosis are not clear. Thus, we aimed to analyse the expression profile and progno...

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Autores principales: Du, Jiali, Gu, Jichun, Deng, Junyuan, Kong, Lei, Guo, Yujie, Jin, Chen, Bao, Yun, Fu, Deliang, Li, Ji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796473/
https://www.ncbi.nlm.nih.gov/pubmed/35090421
http://dx.doi.org/10.1186/s12885-021-09060-4
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author Du, Jiali
Gu, Jichun
Deng, Junyuan
Kong, Lei
Guo, Yujie
Jin, Chen
Bao, Yun
Fu, Deliang
Li, Ji
author_facet Du, Jiali
Gu, Jichun
Deng, Junyuan
Kong, Lei
Guo, Yujie
Jin, Chen
Bao, Yun
Fu, Deliang
Li, Ji
author_sort Du, Jiali
collection PubMed
description BACKGROUND: Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with prognosis are not clear. Thus, we aimed to analyse the expression profile and prognostic significance of SGLT-1 and SGLT-2 in PC. METHODS: Eighty-eight patients with pancreatic ductal adenocarcinoma (PDAC) undergoing surgery in Huashan Hospital, Fudan University, from July 2017 to June 2020 were enrolled in the study. Specimens for immunohistochemistry were obtained through surgical resection. Bioinformatics analysis was performed based on the Gene Expression Omnibus (GEO), Oncomine and The Cancer Genome Atlas (TCGA) databases. The statistics were calculated using IBM SPSS Statistics, version 20 and R 4.1.1. P values lower than 0.05 were considered to indicate statistical significance. RESULTS: SGLT-1 but not SGLT-2 was significantly overexpressed in PDAC. Survival analysis showed that the median overall survival (OS) and progression-free survival (PFS) of patients with high SGLT-1 expression were significantly longer than that of patients with low SGLT-1 expression. Cox regression indicated that high SGLT-1 expression was an independent predictor for a better prognosis, while residual tumour status (R1 and R2) was an independent risk factor for a poor prognosis. Finally, PDZK1-interacting protein 1 (PDZK1IP1), a protein participating in the generation of reactive oxygen species, was overexpressed in PDAC and its expression was significantly correlated with SGLT-1. CONCLUSIONS: SGLT-1 but not SGLT-2 was overexpressed in PDAC, and the overexpression of SGLT-1 could be a predictor of a better prognosis. Residual tumour status (R1 and R2) was a risk factor for poor prognosis and disease progression. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-09060-4.
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spelling pubmed-87964732022-02-03 The expression and survival significance of sodium glucose transporters in pancreatic cancer Du, Jiali Gu, Jichun Deng, Junyuan Kong, Lei Guo, Yujie Jin, Chen Bao, Yun Fu, Deliang Li, Ji BMC Cancer Research BACKGROUND: Sodium glucose transporters (SGLTs) play vital roles in glucose uptake in many solid cancers, including pancreatic cancer (PC). However, their expression profile in pancreatic cancer and correlation with prognosis are not clear. Thus, we aimed to analyse the expression profile and prognostic significance of SGLT-1 and SGLT-2 in PC. METHODS: Eighty-eight patients with pancreatic ductal adenocarcinoma (PDAC) undergoing surgery in Huashan Hospital, Fudan University, from July 2017 to June 2020 were enrolled in the study. Specimens for immunohistochemistry were obtained through surgical resection. Bioinformatics analysis was performed based on the Gene Expression Omnibus (GEO), Oncomine and The Cancer Genome Atlas (TCGA) databases. The statistics were calculated using IBM SPSS Statistics, version 20 and R 4.1.1. P values lower than 0.05 were considered to indicate statistical significance. RESULTS: SGLT-1 but not SGLT-2 was significantly overexpressed in PDAC. Survival analysis showed that the median overall survival (OS) and progression-free survival (PFS) of patients with high SGLT-1 expression were significantly longer than that of patients with low SGLT-1 expression. Cox regression indicated that high SGLT-1 expression was an independent predictor for a better prognosis, while residual tumour status (R1 and R2) was an independent risk factor for a poor prognosis. Finally, PDZK1-interacting protein 1 (PDZK1IP1), a protein participating in the generation of reactive oxygen species, was overexpressed in PDAC and its expression was significantly correlated with SGLT-1. CONCLUSIONS: SGLT-1 but not SGLT-2 was overexpressed in PDAC, and the overexpression of SGLT-1 could be a predictor of a better prognosis. Residual tumour status (R1 and R2) was a risk factor for poor prognosis and disease progression. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12885-021-09060-4. BioMed Central 2022-01-28 /pmc/articles/PMC8796473/ /pubmed/35090421 http://dx.doi.org/10.1186/s12885-021-09060-4 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Du, Jiali
Gu, Jichun
Deng, Junyuan
Kong, Lei
Guo, Yujie
Jin, Chen
Bao, Yun
Fu, Deliang
Li, Ji
The expression and survival significance of sodium glucose transporters in pancreatic cancer
title The expression and survival significance of sodium glucose transporters in pancreatic cancer
title_full The expression and survival significance of sodium glucose transporters in pancreatic cancer
title_fullStr The expression and survival significance of sodium glucose transporters in pancreatic cancer
title_full_unstemmed The expression and survival significance of sodium glucose transporters in pancreatic cancer
title_short The expression and survival significance of sodium glucose transporters in pancreatic cancer
title_sort expression and survival significance of sodium glucose transporters in pancreatic cancer
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796473/
https://www.ncbi.nlm.nih.gov/pubmed/35090421
http://dx.doi.org/10.1186/s12885-021-09060-4
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