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Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis
Children with cystic fibrosis (CF) constitute a high-risk group for COVID-19 with underlying chronic lung disease. COVID-19 severity varying from mild infection to need of intensive care has been described in children with CF. Two children with significant underlying pulmonary morbidity are describe...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer India
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796594/ https://www.ncbi.nlm.nih.gov/pubmed/35089489 http://dx.doi.org/10.1007/s12098-021-04057-0 |
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author | Dhochak, Nitin Jat, Kana Ram Soni, Kapil Dev Singh, Yudhyavir Aggarwal, Richa Lodha, Rakesh Trikha, Anjan Kabra, Sushil K. |
author_facet | Dhochak, Nitin Jat, Kana Ram Soni, Kapil Dev Singh, Yudhyavir Aggarwal, Richa Lodha, Rakesh Trikha, Anjan Kabra, Sushil K. |
author_sort | Dhochak, Nitin |
collection | PubMed |
description | Children with cystic fibrosis (CF) constitute a high-risk group for COVID-19 with underlying chronic lung disease. COVID-19 severity varying from mild infection to need of intensive care has been described in children with CF. Two children with significant underlying pulmonary morbidity are described here, who developed severe disease following SARS-CoV-2 infection. Case 1 (a 9-y-old boy) had pneumonia with respiratory failure requiring noninvasive ventilation support. He had delayed clearance of SARS-CoV-2, with recurrence of symptomatic disease with short asymptomatic period in between. He was also diagnosed with CF-related diabetes and allergic bronchopulmonary aspergillosis during the second episode. Case 2 (an 18-mo-old boy) had two episodes of SARS-CoV-2–related severe lower respiratory infection within a period of 2 mo, requiring high-flow nasal oxygen support. Both children had 3(rd) pulmonary exacerbation but SARS-CoV-2 was not detected in respiratory secretions. To conclude, children with CF with underlying pulmonary morbidity, can develop severe COVID-19 and prolonged SARS-CoV-2 shedding. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12098-021-04057-0. |
format | Online Article Text |
id | pubmed-8796594 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Springer India |
record_format | MEDLINE/PubMed |
spelling | pubmed-87965942022-01-31 Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis Dhochak, Nitin Jat, Kana Ram Soni, Kapil Dev Singh, Yudhyavir Aggarwal, Richa Lodha, Rakesh Trikha, Anjan Kabra, Sushil K. Indian J Pediatr Clinical Brief Children with cystic fibrosis (CF) constitute a high-risk group for COVID-19 with underlying chronic lung disease. COVID-19 severity varying from mild infection to need of intensive care has been described in children with CF. Two children with significant underlying pulmonary morbidity are described here, who developed severe disease following SARS-CoV-2 infection. Case 1 (a 9-y-old boy) had pneumonia with respiratory failure requiring noninvasive ventilation support. He had delayed clearance of SARS-CoV-2, with recurrence of symptomatic disease with short asymptomatic period in between. He was also diagnosed with CF-related diabetes and allergic bronchopulmonary aspergillosis during the second episode. Case 2 (an 18-mo-old boy) had two episodes of SARS-CoV-2–related severe lower respiratory infection within a period of 2 mo, requiring high-flow nasal oxygen support. Both children had 3(rd) pulmonary exacerbation but SARS-CoV-2 was not detected in respiratory secretions. To conclude, children with CF with underlying pulmonary morbidity, can develop severe COVID-19 and prolonged SARS-CoV-2 shedding. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1007/s12098-021-04057-0. Springer India 2022-01-28 2022 /pmc/articles/PMC8796594/ /pubmed/35089489 http://dx.doi.org/10.1007/s12098-021-04057-0 Text en © Dr. K C Chaudhuri Foundation 2022 This article is made available via the PMC Open Access Subset for unrestricted research re-use and secondary analysis in any form or by any means with acknowledgement of the original source. These permissions are granted for the duration of the World Health Organization (WHO) declaration of COVID-19 as a global pandemic. |
spellingShingle | Clinical Brief Dhochak, Nitin Jat, Kana Ram Soni, Kapil Dev Singh, Yudhyavir Aggarwal, Richa Lodha, Rakesh Trikha, Anjan Kabra, Sushil K. Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis |
title | Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis |
title_full | Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis |
title_fullStr | Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis |
title_full_unstemmed | Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis |
title_short | Poor Respiratory Health Following Relapsing SARS-CoV-2 Infection in Children with Cystic Fibrosis |
title_sort | poor respiratory health following relapsing sars-cov-2 infection in children with cystic fibrosis |
topic | Clinical Brief |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796594/ https://www.ncbi.nlm.nih.gov/pubmed/35089489 http://dx.doi.org/10.1007/s12098-021-04057-0 |
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