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TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study

BACKGROUND: Polymorphisms at positions 49, 262, and 296 in the TAS2R38 bitter taste receptor gene result in two common genetic haplotypes, PAV and AVI, named for the resulting amino acid substitutions. TAS2R38 genotype has been previously associated with caries risk in children. This study aimed to...

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Autores principales: Khimsuksri, Sawita, Paphangkorakit, Jarin, Pitiphat, Waranuch, Coldwell, Susan Elaine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796631/
https://www.ncbi.nlm.nih.gov/pubmed/35090440
http://dx.doi.org/10.1186/s12903-022-02043-2
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author Khimsuksri, Sawita
Paphangkorakit, Jarin
Pitiphat, Waranuch
Coldwell, Susan Elaine
author_facet Khimsuksri, Sawita
Paphangkorakit, Jarin
Pitiphat, Waranuch
Coldwell, Susan Elaine
author_sort Khimsuksri, Sawita
collection PubMed
description BACKGROUND: Polymorphisms at positions 49, 262, and 296 in the TAS2R38 bitter taste receptor gene result in two common genetic haplotypes, PAV and AVI, named for the resulting amino acid substitutions. TAS2R38 genotype has been previously associated with caries risk in children. This study aimed to identify TAS2R38 polymorphisms among Thais and to explore any association between genotype and oral diseases. METHODS: Patients seeking care at Khon Kaen University Dental Hospital in Thailand were recruited to participate in the study. Saliva was collected for DNA extraction and genotyping. Patients completed a questionnaire to collect demographic variables and assess oral self-care behaviors. A calibrated dentist conducted an examination that included periodontal charting and recording of decayed, missing, and filled teeth (DMFT). RESULTS: A total of 250 patients (19–75 years) were enrolled in the study (116 males). Two haplotypes, PAV (67.2%) and AVI (32.8%) were found, resulting in 3 diplotypes; PAV/PAV (46.0%), PAV/AVI (42.4%) and AVI/AVI (11.6%). DMFT and periodontal status of 238 participants were recorded. The three diplotype groups were similar in age, sex, socio-economic indicators, oral self-care, and number of teeth. The odds of having periodontal disease, defined as at least one site with probing depth ≥ 5 mm, were lower in AVI/AVI and PAV/AVI compared with PAV/PAV. PAV/AVI tended to have less DMFT, while AVI/AVI tended to have more DMFT compared with PAV/PAV, however these trends did not reach statistical significance. CONCLUSIONS: The frequency distribution of TAS2R38 genotypes was similar to that reported for other Asian populations. AVI/AVI genotype was associated with decreased prevalence of periodontal disease among Thai dental patients, whereas there was no significant association between TAS2R38 genotype and prevalence of tooth decay in this patient population.
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spelling pubmed-87966312022-02-03 TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study Khimsuksri, Sawita Paphangkorakit, Jarin Pitiphat, Waranuch Coldwell, Susan Elaine BMC Oral Health Research BACKGROUND: Polymorphisms at positions 49, 262, and 296 in the TAS2R38 bitter taste receptor gene result in two common genetic haplotypes, PAV and AVI, named for the resulting amino acid substitutions. TAS2R38 genotype has been previously associated with caries risk in children. This study aimed to identify TAS2R38 polymorphisms among Thais and to explore any association between genotype and oral diseases. METHODS: Patients seeking care at Khon Kaen University Dental Hospital in Thailand were recruited to participate in the study. Saliva was collected for DNA extraction and genotyping. Patients completed a questionnaire to collect demographic variables and assess oral self-care behaviors. A calibrated dentist conducted an examination that included periodontal charting and recording of decayed, missing, and filled teeth (DMFT). RESULTS: A total of 250 patients (19–75 years) were enrolled in the study (116 males). Two haplotypes, PAV (67.2%) and AVI (32.8%) were found, resulting in 3 diplotypes; PAV/PAV (46.0%), PAV/AVI (42.4%) and AVI/AVI (11.6%). DMFT and periodontal status of 238 participants were recorded. The three diplotype groups were similar in age, sex, socio-economic indicators, oral self-care, and number of teeth. The odds of having periodontal disease, defined as at least one site with probing depth ≥ 5 mm, were lower in AVI/AVI and PAV/AVI compared with PAV/PAV. PAV/AVI tended to have less DMFT, while AVI/AVI tended to have more DMFT compared with PAV/PAV, however these trends did not reach statistical significance. CONCLUSIONS: The frequency distribution of TAS2R38 genotypes was similar to that reported for other Asian populations. AVI/AVI genotype was associated with decreased prevalence of periodontal disease among Thai dental patients, whereas there was no significant association between TAS2R38 genotype and prevalence of tooth decay in this patient population. BioMed Central 2022-01-28 /pmc/articles/PMC8796631/ /pubmed/35090440 http://dx.doi.org/10.1186/s12903-022-02043-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research
Khimsuksri, Sawita
Paphangkorakit, Jarin
Pitiphat, Waranuch
Coldwell, Susan Elaine
TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study
title TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study
title_full TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study
title_fullStr TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study
title_full_unstemmed TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study
title_short TAS2R38 polymorphisms and oral diseases in Thais: a cross-sectional study
title_sort tas2r38 polymorphisms and oral diseases in thais: a cross-sectional study
topic Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8796631/
https://www.ncbi.nlm.nih.gov/pubmed/35090440
http://dx.doi.org/10.1186/s12903-022-02043-2
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