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Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series

Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy. Intermittent hemodialysis is recommended, as it achieves rapid more elimination of metformin compared to continuous renal replacement therapy (CRRT). This case series describe...

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Detalles Bibliográficos
Autores principales: Reynolds, Hannah V., Pollock, Hamish H. G., Apte, Yogesh V., Tabah, Alexis
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Lippincott Williams & Wilkins 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797005/
https://www.ncbi.nlm.nih.gov/pubmed/35050908
http://dx.doi.org/10.1213/XAA.0000000000001561
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author Reynolds, Hannah V.
Pollock, Hamish H. G.
Apte, Yogesh V.
Tabah, Alexis
author_facet Reynolds, Hannah V.
Pollock, Hamish H. G.
Apte, Yogesh V.
Tabah, Alexis
author_sort Reynolds, Hannah V.
collection PubMed
description Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy. Intermittent hemodialysis is recommended, as it achieves rapid more elimination of metformin compared to continuous renal replacement therapy (CRRT). This case series describes 4 patients, 2 with acute metformin intoxications and 2 with insidious metformin toxicity. All were treated using a novel approach with dual CRRT to achieve rapid elimination of metformin. Three of the 4 patients survived to hospital discharge. Dual CRRT may be an effective alternative when dialysis is not readily available.
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spelling pubmed-87970052022-01-31 Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series Reynolds, Hannah V. Pollock, Hamish H. G. Apte, Yogesh V. Tabah, Alexis A A Pract Case Series Severe and life-threatening cases of metformin-associated lactic acidosis (MALA) are treated with renal replacement therapy. Intermittent hemodialysis is recommended, as it achieves rapid more elimination of metformin compared to continuous renal replacement therapy (CRRT). This case series describes 4 patients, 2 with acute metformin intoxications and 2 with insidious metformin toxicity. All were treated using a novel approach with dual CRRT to achieve rapid elimination of metformin. Three of the 4 patients survived to hospital discharge. Dual CRRT may be an effective alternative when dialysis is not readily available. Lippincott Williams & Wilkins 2022-01-18 /pmc/articles/PMC8797005/ /pubmed/35050908 http://dx.doi.org/10.1213/XAA.0000000000001561 Text en Copyright © 2022 International Anesthesia Research Society. https://creativecommons.org/licenses/by-nc-nd/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND) (https://creativecommons.org/licenses/by-nc-nd/4.0/) , where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.
spellingShingle Case Series
Reynolds, Hannah V.
Pollock, Hamish H. G.
Apte, Yogesh V.
Tabah, Alexis
Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
title Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
title_full Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
title_fullStr Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
title_full_unstemmed Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
title_short Achieving High Dialysis Dose via Continuous Renal Replacement Therapy in the Setting of Metformin Associated Lactic Acidosis. A Case Series
title_sort achieving high dialysis dose via continuous renal replacement therapy in the setting of metformin associated lactic acidosis. a case series
topic Case Series
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797005/
https://www.ncbi.nlm.nih.gov/pubmed/35050908
http://dx.doi.org/10.1213/XAA.0000000000001561
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