DAMPs/PAMPs induce monocytic TLR activation and tolerance in COVID-19 patients; nucleic acid binding scavengers can counteract such TLR agonists

Millions of COVID-19 patients have succumbed to respiratory and systemic inflammation. Hyperstimulation of toll-like receptor (TLR) signaling is a key driver of immunopathology following infection by viruses. We found that severely ill COVID-19 patients in the Intensive Care Unit (ICU) display hallm...

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Detalles Bibliográficos
Autores principales: Naqvi, Ibtehaj, Giroux, Nicholas, Olson, Lyra, Morrison, Sarah Ahn, Llanga, Telmo, Akinade, Tolu O., Zhu, Yuefei, Zhong, Yiling, Bose, Shree, Arvai, Stephanie, Abramson, Karen, Chen, Lingye, Que, Loretta, Kraft, Bryan, Shen, Xiling, Lee, Jaewoo, Leong, Kam W., Nair, Smita K., Sullenger, Bruce
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Ltd. 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797062/
https://www.ncbi.nlm.nih.gov/pubmed/35349874
http://dx.doi.org/10.1016/j.biomaterials.2022.121393

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