The ingenol-based protein kinase C agonist GSK445A is a potent inducer of HIV and SIV RNA transcription

Activation of the NF-κB signaling pathway by Protein Kinase C (PKC) agonists is a potent mechanism for human immunodeficiency virus (HIV) latency disruption in vitro. However, significant toxicity risks and the lack of evidence supporting their activity in vivo have limited further evaluation of PKC...

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Detalles Bibliográficos
Autores principales: Okoye, Afam A., Fromentin, Rémi, Takata, Hiroshi, Brehm, Jessica H., Fukazawa, Yoshinori, Randall, Bryan, Pardons, Marion, Tai, Vincent, Tang, Jun, Smedley, Jeremy, Axthelm, Michael, Lifson, Jeffrey D., Picker, Louis J., Favre, David, Trautmann, Lydie, Chomont, Nicolas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797195/
https://www.ncbi.nlm.nih.gov/pubmed/35041707
http://dx.doi.org/10.1371/journal.ppat.1010245

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