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Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure
BACKGROUND: This study aimed to investigate the association between changes in brain natriuretic peptide (BNP) from discharge to 6-month visit and subsequent clinical outcomes in patients with acute heart failure (AHF). METHODS: Among 1246 patients enrolled in the prospective longitudinal follow-up...
Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797237/ https://www.ncbi.nlm.nih.gov/pubmed/35089974 http://dx.doi.org/10.1371/journal.pone.0263165 |
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author | Shiba, Masayuki Kato, Takao Morimoto, Takeshi Yaku, Hidenori Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Seko, Yuta Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Yamashita, Yugo Iguchi, Moritake Nagao, Kazuya Kawase, Yuichi Morinaga, Takashi Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Nakagawa, Yasuaki Kuwahara, Koichiro Kimura, Takeshi |
author_facet | Shiba, Masayuki Kato, Takao Morimoto, Takeshi Yaku, Hidenori Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Seko, Yuta Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Yamashita, Yugo Iguchi, Moritake Nagao, Kazuya Kawase, Yuichi Morinaga, Takashi Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Nakagawa, Yasuaki Kuwahara, Koichiro Kimura, Takeshi |
author_sort | Shiba, Masayuki |
collection | PubMed |
description | BACKGROUND: This study aimed to investigate the association between changes in brain natriuretic peptide (BNP) from discharge to 6-month visit and subsequent clinical outcomes in patients with acute heart failure (AHF). METHODS: Among 1246 patients enrolled in the prospective longitudinal follow-up study nested from the Kyoto Congestive Heart Failure registry, this study population included 446 patients with available paired BNP data at discharge and 6-month index visit. This study population was classified into 3 groups by percent change in BNP from discharge to 6-month visit; the low tertile (≤-44%, N = 149), the middle tertile (>-44% and ≤22%, N = 149) and the high tertile (>22%, N = 148). FINDINGS: The cumulative 180-day incidence after the index visit of the primary outcome measure (a composite endpoint of all-cause death or hospitalization for HF) was significantly higher in the high and middle tertiles than in the low tertile (26.8% and 14.4% versus 6.9%, log-rank P<0.0001). The adjusted excess risk of the high tertile relative to the low tertile remained significant for the primary outcome measure (hazard ratio: 3.43, 95% confidence interval: 1.51–8.46, P = 0.003). CONCLUSIONS: Percent change in BNP was associated with a subsequent risk for a composite of all-cause death and hospitalization for HF after adjustment of the absolute BNP values, suggesting that observing the change in BNP levels, in addition to absolute BNP levels themselves, helps us to manage patient with HF. |
format | Online Article Text |
id | pubmed-8797237 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-87972372022-01-29 Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure Shiba, Masayuki Kato, Takao Morimoto, Takeshi Yaku, Hidenori Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Seko, Yuta Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Yamashita, Yugo Iguchi, Moritake Nagao, Kazuya Kawase, Yuichi Morinaga, Takashi Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Nakagawa, Yasuaki Kuwahara, Koichiro Kimura, Takeshi PLoS One Research Article BACKGROUND: This study aimed to investigate the association between changes in brain natriuretic peptide (BNP) from discharge to 6-month visit and subsequent clinical outcomes in patients with acute heart failure (AHF). METHODS: Among 1246 patients enrolled in the prospective longitudinal follow-up study nested from the Kyoto Congestive Heart Failure registry, this study population included 446 patients with available paired BNP data at discharge and 6-month index visit. This study population was classified into 3 groups by percent change in BNP from discharge to 6-month visit; the low tertile (≤-44%, N = 149), the middle tertile (>-44% and ≤22%, N = 149) and the high tertile (>22%, N = 148). FINDINGS: The cumulative 180-day incidence after the index visit of the primary outcome measure (a composite endpoint of all-cause death or hospitalization for HF) was significantly higher in the high and middle tertiles than in the low tertile (26.8% and 14.4% versus 6.9%, log-rank P<0.0001). The adjusted excess risk of the high tertile relative to the low tertile remained significant for the primary outcome measure (hazard ratio: 3.43, 95% confidence interval: 1.51–8.46, P = 0.003). CONCLUSIONS: Percent change in BNP was associated with a subsequent risk for a composite of all-cause death and hospitalization for HF after adjustment of the absolute BNP values, suggesting that observing the change in BNP levels, in addition to absolute BNP levels themselves, helps us to manage patient with HF. Public Library of Science 2022-01-28 /pmc/articles/PMC8797237/ /pubmed/35089974 http://dx.doi.org/10.1371/journal.pone.0263165 Text en © 2022 Shiba et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shiba, Masayuki Kato, Takao Morimoto, Takeshi Yaku, Hidenori Inuzuka, Yasutaka Tamaki, Yodo Ozasa, Neiko Seko, Yuta Yamamoto, Erika Yoshikawa, Yusuke Kitai, Takeshi Yamashita, Yugo Iguchi, Moritake Nagao, Kazuya Kawase, Yuichi Morinaga, Takashi Toyofuku, Mamoru Furukawa, Yutaka Ando, Kenji Kadota, Kazushige Sato, Yukihito Nakagawa, Yasuaki Kuwahara, Koichiro Kimura, Takeshi Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure |
title | Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure |
title_full | Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure |
title_fullStr | Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure |
title_full_unstemmed | Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure |
title_short | Changes in BNP levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure |
title_sort | changes in bnp levels from discharge to 6-month visit predict subsequent outcomes in patients with acute heart failure |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797237/ https://www.ncbi.nlm.nih.gov/pubmed/35089974 http://dx.doi.org/10.1371/journal.pone.0263165 |
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