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Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review
BACKGROUND: The study aims to retrospectively evaluate disparate reconstructive choices for defects in patients with primary hypopharyngeal carcinoma undergoing tumor resection. METHODS: One hundred and twenty-five patients of primary hypopharyngeal carcinamo conducted with hypopharynx reconstructio...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797281/ https://www.ncbi.nlm.nih.gov/pubmed/35116630 http://dx.doi.org/10.21037/tcr-20-2910 |
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author | Heng, Yu Zhang, Duo Zhu, Xiaoke Zhou, Liang Zhang, Ming Li, Kenan Tao, Lei |
author_facet | Heng, Yu Zhang, Duo Zhu, Xiaoke Zhou, Liang Zhang, Ming Li, Kenan Tao, Lei |
author_sort | Heng, Yu |
collection | PubMed |
description | BACKGROUND: The study aims to retrospectively evaluate disparate reconstructive choices for defects in patients with primary hypopharyngeal carcinoma undergoing tumor resection. METHODS: One hundred and twenty-five patients of primary hypopharyngeal carcinamo conducted with hypopharynx reconstruction for restoring the defects causing by tumor ablation from 2003 to 2016 at Eye & ENT Hospital of Fudan University were reviewed. Most of them were treated with the following three techniques (n=115): gastric pull-up (GPU), the pedicled pectoralis major myocutaneous flap (PMMF) and the radial forearm free flap (RFFF). GPU was used for those with cervical esophagus invasion requiring esophageal resection in our institution. We focus on the postoperative complication morbidity, function of deglutition 1 month after hospital discharge and disease-free survival (DFS) outcomes. RESULTS: One month after operation, 56 of 65 (86.2%) achieved solid or semisolid diet with normal swallowing function for GPU, 8 of 12 (66.7%) for RFFF and 20 of 33 (60.6%) for PMMF respectively. Postoperative complications occured in 15 (23.1%), 8 (66.7%), 16 (48.5%) for GPU, RFFF and PMMF respectively, including flap/anastomotic necrsis, pharyngeal fistula, wound infection (both recipient and donor sites), pulmonary and cardiovascular complications. CONCLUSIONS: GPU showed satisfactory outcomes for reconstruction of patients with hypopharyngeal carcinoma requiring esophageal resection. For patients without cervical esophagus invasion and underwent partial or total pharyngectomy, both PMMF and RFFF can afford good coverage and reliable functional and survival outcome as well as postoperative complication morbidity. Moreover, the only predictive factor for incidence of postoperative complication was extent of surgery, as total hypopharyngectomy was more likely to develop complications after surgery than partial hypopharyngectomy. |
format | Online Article Text |
id | pubmed-8797281 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87972812022-02-02 Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review Heng, Yu Zhang, Duo Zhu, Xiaoke Zhou, Liang Zhang, Ming Li, Kenan Tao, Lei Transl Cancer Res Original Article BACKGROUND: The study aims to retrospectively evaluate disparate reconstructive choices for defects in patients with primary hypopharyngeal carcinoma undergoing tumor resection. METHODS: One hundred and twenty-five patients of primary hypopharyngeal carcinamo conducted with hypopharynx reconstruction for restoring the defects causing by tumor ablation from 2003 to 2016 at Eye & ENT Hospital of Fudan University were reviewed. Most of them were treated with the following three techniques (n=115): gastric pull-up (GPU), the pedicled pectoralis major myocutaneous flap (PMMF) and the radial forearm free flap (RFFF). GPU was used for those with cervical esophagus invasion requiring esophageal resection in our institution. We focus on the postoperative complication morbidity, function of deglutition 1 month after hospital discharge and disease-free survival (DFS) outcomes. RESULTS: One month after operation, 56 of 65 (86.2%) achieved solid or semisolid diet with normal swallowing function for GPU, 8 of 12 (66.7%) for RFFF and 20 of 33 (60.6%) for PMMF respectively. Postoperative complications occured in 15 (23.1%), 8 (66.7%), 16 (48.5%) for GPU, RFFF and PMMF respectively, including flap/anastomotic necrsis, pharyngeal fistula, wound infection (both recipient and donor sites), pulmonary and cardiovascular complications. CONCLUSIONS: GPU showed satisfactory outcomes for reconstruction of patients with hypopharyngeal carcinoma requiring esophageal resection. For patients without cervical esophagus invasion and underwent partial or total pharyngectomy, both PMMF and RFFF can afford good coverage and reliable functional and survival outcome as well as postoperative complication morbidity. Moreover, the only predictive factor for incidence of postoperative complication was extent of surgery, as total hypopharyngectomy was more likely to develop complications after surgery than partial hypopharyngectomy. AME Publishing Company 2021-07 /pmc/articles/PMC8797281/ /pubmed/35116630 http://dx.doi.org/10.21037/tcr-20-2910 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Article Heng, Yu Zhang, Duo Zhu, Xiaoke Zhou, Liang Zhang, Ming Li, Kenan Tao, Lei Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review |
title | Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review |
title_full | Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review |
title_fullStr | Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review |
title_full_unstemmed | Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review |
title_short | Hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review |
title_sort | hypopharynx reconstruction for primary hypopharyngeal carcinoma: a retrospective study and literature review |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797281/ https://www.ncbi.nlm.nih.gov/pubmed/35116630 http://dx.doi.org/10.21037/tcr-20-2910 |
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