Cargando…

The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE)

BACKGROUND: This study aimed to evaluate whether corona enhancement and intratumor perfusion features of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) predict short-term tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in pa...

Descripción completa

Detalles Bibliográficos
Autores principales: Fei, Xiang, Wang, Zhi-Jun, Li, Ye, Han, Peng, Li, Xiao-Hui, Jiang, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797303/
https://www.ncbi.nlm.nih.gov/pubmed/35117723
http://dx.doi.org/10.21037/tcr.2020.04.17
_version_ 1784641518316814336
author Fei, Xiang
Wang, Zhi-Jun
Li, Ye
Han, Peng
Li, Xiao-Hui
Jiang, Bo
author_facet Fei, Xiang
Wang, Zhi-Jun
Li, Ye
Han, Peng
Li, Xiao-Hui
Jiang, Bo
author_sort Fei, Xiang
collection PubMed
description BACKGROUND: This study aimed to evaluate whether corona enhancement and intratumor perfusion features of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) predict short-term tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). METHODS: This trial included 39 patients with 51 HCC target lesions who underwent cTACE with IA-CEUS. The maximum cross-sectional area ratio of intratumor perfusion between pre- and post-procedure, as well as the peak value and sickness of corona enhancement immediately post-cTACE were measured respectively. Tumor response at MRI was assessed according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) guidelines. Nonparametric Spearman rank-order correlation was used to correlate the maximum cross-sectional area ratio of intratumor perfusion, the peak value, and sickness of corona enhancement of IA-CEUS immediately after cTACE with tumor response. RESULTS: The results showed that 39 patients with 51 target lesions were assessed for tumor response. Complete remission (CR), partial remission (PR), stable disease (SD), and progressive disease (PD) were 22 (43.1%), 14 (27.5%), 10 (19.6%), and 5 (9.8%), respectively. The maximum cross-sectional area ratio of intratumor perfusion moderately correlated with tumor response on CE-MRI (Spearman rho =0.513, P<0.001). Furthermore, the peak value and sickness of corona enhancement showed a good correlation with tumor response on CE-MRI respectively (Spearman rho =0.671, P<0.001, rho =0.704, P<0.001). CONCLUSIONS: Intra-procedural transcatheter IA-CEUS may predict short-term tumor response in cTACE of HCC. The feature of corona enhancement immediately post-cTACE also showed a more accurate prediction when compared with the feature of intratumor infusion (rho =0.671).
format Online
Article
Text
id pubmed-8797303
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-87973032022-02-02 The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE) Fei, Xiang Wang, Zhi-Jun Li, Ye Han, Peng Li, Xiao-Hui Jiang, Bo Transl Cancer Res Original Article BACKGROUND: This study aimed to evaluate whether corona enhancement and intratumor perfusion features of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) predict short-term tumor response on follow-up contrast-enhanced magnetic resonance imaging (CE-MRI) in patients with hepatocellular carcinoma (HCC) treated with conventional transarterial chemoembolization (cTACE). METHODS: This trial included 39 patients with 51 HCC target lesions who underwent cTACE with IA-CEUS. The maximum cross-sectional area ratio of intratumor perfusion between pre- and post-procedure, as well as the peak value and sickness of corona enhancement immediately post-cTACE were measured respectively. Tumor response at MRI was assessed according to modified Response Evaluation Criteria in Solid Tumors (mRECIST) guidelines. Nonparametric Spearman rank-order correlation was used to correlate the maximum cross-sectional area ratio of intratumor perfusion, the peak value, and sickness of corona enhancement of IA-CEUS immediately after cTACE with tumor response. RESULTS: The results showed that 39 patients with 51 target lesions were assessed for tumor response. Complete remission (CR), partial remission (PR), stable disease (SD), and progressive disease (PD) were 22 (43.1%), 14 (27.5%), 10 (19.6%), and 5 (9.8%), respectively. The maximum cross-sectional area ratio of intratumor perfusion moderately correlated with tumor response on CE-MRI (Spearman rho =0.513, P<0.001). Furthermore, the peak value and sickness of corona enhancement showed a good correlation with tumor response on CE-MRI respectively (Spearman rho =0.671, P<0.001, rho =0.704, P<0.001). CONCLUSIONS: Intra-procedural transcatheter IA-CEUS may predict short-term tumor response in cTACE of HCC. The feature of corona enhancement immediately post-cTACE also showed a more accurate prediction when compared with the feature of intratumor infusion (rho =0.671). AME Publishing Company 2020-05 /pmc/articles/PMC8797303/ /pubmed/35117723 http://dx.doi.org/10.21037/tcr.2020.04.17 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Fei, Xiang
Wang, Zhi-Jun
Li, Ye
Han, Peng
Li, Xiao-Hui
Jiang, Bo
The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE)
title The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE)
title_full The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE)
title_fullStr The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE)
title_full_unstemmed The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE)
title_short The value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (IA-CEUS) in predicting the short-term efficacy of conventional transarterial chemoembolization (cTACE)
title_sort value of intra-procedural transcatheter intraarterial contrast-enhanced ultrasonography (ia-ceus) in predicting the short-term efficacy of conventional transarterial chemoembolization (ctace)
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797303/
https://www.ncbi.nlm.nih.gov/pubmed/35117723
http://dx.doi.org/10.21037/tcr.2020.04.17
work_keys_str_mv AT feixiang thevalueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT wangzhijun thevalueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT liye thevalueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT hanpeng thevalueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT lixiaohui thevalueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT jiangbo thevalueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT feixiang valueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT wangzhijun valueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT liye valueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT hanpeng valueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT lixiaohui valueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace
AT jiangbo valueofintraproceduraltranscatheterintraarterialcontrastenhancedultrasonographyiaceusinpredictingtheshorttermefficacyofconventionaltransarterialchemoembolizationctace