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A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report

An inflammatory pseudotumor is considered a benign form of lesion marked by a proliferation of myofibroblasts with different degrees of inflammatory infiltrates. Pulmonary inflammatory pseudotumors (PIPs) are extremely rare in middle-aged adults. Normally, a PIP has a single lesion, and can be contr...

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Autores principales: Li, Na, Zou, Changpeng, Gao, Siming, Guo, Ying, Wang, Wei, Guo, Yan, Zhang, Juan, Wang, Cong, An, Yonghui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797402/
https://www.ncbi.nlm.nih.gov/pubmed/35116517
http://dx.doi.org/10.21037/tcr-21-564
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author Li, Na
Zou, Changpeng
Gao, Siming
Guo, Ying
Wang, Wei
Guo, Yan
Zhang, Juan
Wang, Cong
An, Yonghui
author_facet Li, Na
Zou, Changpeng
Gao, Siming
Guo, Ying
Wang, Wei
Guo, Yan
Zhang, Juan
Wang, Cong
An, Yonghui
author_sort Li, Na
collection PubMed
description An inflammatory pseudotumor is considered a benign form of lesion marked by a proliferation of myofibroblasts with different degrees of inflammatory infiltrates. Pulmonary inflammatory pseudotumors (PIPs) are extremely rare in middle-aged adults. Normally, a PIP has a single lesion, and can be controlled constantly by surgery and drugs. In this paper, we report a case study of a 51-year-old male patient who presented with multiple inflammatory pseudotumors in lungs, thoracic spine, ribs, left humerusl, derived from PIPs throughout his body, which indicated a long disease term and significant recrudescence. After 6 surgeries (a wedge resection of the right lower lobe, a removal of three thoracic vertebral lesions, a removal of left humeral tumor lesion, a right lower lobe resection, local cryoablation of right lung, debridement of left upper-arm osteomyelitis and soft tissue infection), radiotherapy for lesions of left humerus destruction at a total dose of 20 Gy/10 F, and systematic treatments (30 mg prednisone acetate daily for 6 weeks, 50 mg compound cyclophosphamide tablets for 2 weeks; antibiotics, blood transfusions, nutritional support), his symptoms improved but reoccurred. The patient ultimately died of septic shock. Our case report highlights that the progression of a PIP to a malignant form requires further research. A multiple-lesion PIP that does not respond to systemic treatment can be highly dangerous.
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spelling pubmed-87974022022-02-02 A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report Li, Na Zou, Changpeng Gao, Siming Guo, Ying Wang, Wei Guo, Yan Zhang, Juan Wang, Cong An, Yonghui Transl Cancer Res Case Report An inflammatory pseudotumor is considered a benign form of lesion marked by a proliferation of myofibroblasts with different degrees of inflammatory infiltrates. Pulmonary inflammatory pseudotumors (PIPs) are extremely rare in middle-aged adults. Normally, a PIP has a single lesion, and can be controlled constantly by surgery and drugs. In this paper, we report a case study of a 51-year-old male patient who presented with multiple inflammatory pseudotumors in lungs, thoracic spine, ribs, left humerusl, derived from PIPs throughout his body, which indicated a long disease term and significant recrudescence. After 6 surgeries (a wedge resection of the right lower lobe, a removal of three thoracic vertebral lesions, a removal of left humeral tumor lesion, a right lower lobe resection, local cryoablation of right lung, debridement of left upper-arm osteomyelitis and soft tissue infection), radiotherapy for lesions of left humerus destruction at a total dose of 20 Gy/10 F, and systematic treatments (30 mg prednisone acetate daily for 6 weeks, 50 mg compound cyclophosphamide tablets for 2 weeks; antibiotics, blood transfusions, nutritional support), his symptoms improved but reoccurred. The patient ultimately died of septic shock. Our case report highlights that the progression of a PIP to a malignant form requires further research. A multiple-lesion PIP that does not respond to systemic treatment can be highly dangerous. AME Publishing Company 2021-04 /pmc/articles/PMC8797402/ /pubmed/35116517 http://dx.doi.org/10.21037/tcr-21-564 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Case Report
Li, Na
Zou, Changpeng
Gao, Siming
Guo, Ying
Wang, Wei
Guo, Yan
Zhang, Juan
Wang, Cong
An, Yonghui
A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report
title A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report
title_full A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report
title_fullStr A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report
title_full_unstemmed A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report
title_short A fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report
title_sort fatal multiple-lesion, inflammatory, pseudotumor in the lung: a rare case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797402/
https://www.ncbi.nlm.nih.gov/pubmed/35116517
http://dx.doi.org/10.21037/tcr-21-564
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