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A feedback circuit of miR-34a/MDM4/p53 regulates apoptosis in chronic lymphocytic leukemia cells

BACKGROUND: Dysfunction of apoptosis is a significant characteristic in chronic lymphocytic leukemia (CLL). Murine double minute 4 (MDM4), miR-34a and TP53 are found to participate in modulating cellular apoptosis while the specific mechanism keeps unclear. This study was designed to investigate the...

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Detalles Bibliográficos
Autores principales:	Cao, Lei, Liu, Yun, Lu, Jin-Bo, Miao, Yi, Du, Xin-Yi, Wang, Rong, Yang, Hui, Xu, Wei, Li, Jian-Yong, Fan, Lei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797636/ https://www.ncbi.nlm.nih.gov/pubmed/35117225 http://dx.doi.org/10.21037/tcr-20-1710

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