A nomogram combined with radiomics features, albuminuria, and metabolic syndrome to predict the risk of myometrial invasion of bladder cancer

BACKGROUND: To establish a preoperative prediction model of myometrial invasion of bladder cancer (BC) based on the radiomics characteristics of multi-parameter thin-slice enhanced computed tomography (CT) imaging. METHODS: Data from 100 patients with BC were analyzed retrospectively. The patients were divided into two groups: muscular invasive BC and non-muscular invasive BC. The tumor region was segmented from enhanced CT images (arterial- and venous-phase calibration maps) of all patients using Slicer-3D software. We extracted 1,223 texture features from tumor image data based on the shape and gray-level co-occurrence matrix, gray size region matrix, gray run-length matrix, adjacent gray difference matrix, and gray correlation matrix. The patients were randomly divided into a training group (n=70) and a verification group (n=30) in a 7:3 ratio. Interclass correlation coefficients >0.75, least absolute shrinkage, and selection operator regression were used for feature selection. The prediction model was established by combining Rad-score, independent clinical factors, and support vector machine (SVM), and a radiomics nomogram was constructed. The nomogram was tested using the consistency index, calibration curve, time-dependent receiver operating characteristic curve, and clinical decision curve to predict the myometrial invasion of the bladder preoperatively. RESULTS: Six radiomics features that were significantly related to myometrial invasion of BC were selected to construct a predictive model. The area under the curve (AUC) values of training group and verification group based on SVM were 0.898 (95% CI: 0.820–0.976) and 0.702 (95% CI: 0.495–0.909), respectively. Single factor and multiple factor analysis showed that albuminuria (95% CI: 0.243–2.206, P=0.0014) and metabolic syndrome (95% CI: 0.850–2.935, P<0.001) were independent influencing factors of BC myometrial invasion. Clinical factors and 11 radiomics features were used to construct a comprehensive model for predicting the pathological grade of BC (radiomics + clinical). After a comprehensive comparison, we found that the overall effectiveness of the model (radiomics + clinical) was the highest (AUC =0.8457). CONCLUSIONS: Based on the multi-parameter thin-layer enhanced CT radiomics feature can be used as a potential independent predictor of BC myometrial invasion, the model based on parameters can initially quantitatively characterize the risk of myometrial invasion, and has excellent potential for predicting myometrial invasion of BC.