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Prognostic risk factors for respiratory failure after esophagectomy

BACKGROUND: Esophagectomy is a high-risk surgical procedure with significant postoperative morbidity and mortality. Respiratory failure is one of the most common complications after esophageal cancer surgery. The purpose of this study was to explore risk factors that affect the recovery of respirato...

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Autores principales: Su, Quanguan, Li, Huan, Yan, Honghong, Wei, Wenxiao, Liao, Wei, Ma, Gang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797711/
https://www.ncbi.nlm.nih.gov/pubmed/35117244
http://dx.doi.org/10.21037/tcr-20-1326a
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author Su, Quanguan
Li, Huan
Yan, Honghong
Wei, Wenxiao
Liao, Wei
Ma, Gang
author_facet Su, Quanguan
Li, Huan
Yan, Honghong
Wei, Wenxiao
Liao, Wei
Ma, Gang
author_sort Su, Quanguan
collection PubMed
description BACKGROUND: Esophagectomy is a high-risk surgical procedure with significant postoperative morbidity and mortality. Respiratory failure is one of the most common complications after esophageal cancer surgery. The purpose of this study was to explore risk factors that affect the recovery of respiratory failure in this kind of patients. METHODS: Totally 2,360 patients underwent esophagectomies with cervical anastomosis or intrathoracic anastomosis in our center from January 2012 to December 2017. Among them, 130 patients with respiratory failure requiring mechanical ventilation were included in the study. The Spearman’s rank correlation test and Mann-Whitney U test were performed to identify the influential factors for the duration of mechanical ventilation. RESULTS: Most patients (81.5%) in this study recovered in the first two weeks of mechanical ventilation, the average duration of mechanical ventilation was 10.1 days. Statistical analysis indicated that lung function test parameters such as FEV(1)/FVC ratio and RV/TLC ratio could have significant influence on the duration of mechanical ventilation. The abnormally increased FEV(1)/FVC ratio and RV/TLC ratio could obviously prolong the ventilation duration. Old age, thrombocytopenia, the elevated creatinine, C-reactive protein (CRP) and lactate could also significantly lengthen the duration of mechanical ventilation. CONCLUSIONS: Abnormally increased FEV(1)/FVC ratio and RV/TLC ratio as well as old age, thrombocytopenia, elevated creatinine, CRP and blood lactate were found to be risk factors for the recovery of patients with respiratory failure after esophagectomies.
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spelling pubmed-87977112022-02-02 Prognostic risk factors for respiratory failure after esophagectomy Su, Quanguan Li, Huan Yan, Honghong Wei, Wenxiao Liao, Wei Ma, Gang Transl Cancer Res Original Article BACKGROUND: Esophagectomy is a high-risk surgical procedure with significant postoperative morbidity and mortality. Respiratory failure is one of the most common complications after esophageal cancer surgery. The purpose of this study was to explore risk factors that affect the recovery of respiratory failure in this kind of patients. METHODS: Totally 2,360 patients underwent esophagectomies with cervical anastomosis or intrathoracic anastomosis in our center from January 2012 to December 2017. Among them, 130 patients with respiratory failure requiring mechanical ventilation were included in the study. The Spearman’s rank correlation test and Mann-Whitney U test were performed to identify the influential factors for the duration of mechanical ventilation. RESULTS: Most patients (81.5%) in this study recovered in the first two weeks of mechanical ventilation, the average duration of mechanical ventilation was 10.1 days. Statistical analysis indicated that lung function test parameters such as FEV(1)/FVC ratio and RV/TLC ratio could have significant influence on the duration of mechanical ventilation. The abnormally increased FEV(1)/FVC ratio and RV/TLC ratio could obviously prolong the ventilation duration. Old age, thrombocytopenia, the elevated creatinine, C-reactive protein (CRP) and lactate could also significantly lengthen the duration of mechanical ventilation. CONCLUSIONS: Abnormally increased FEV(1)/FVC ratio and RV/TLC ratio as well as old age, thrombocytopenia, elevated creatinine, CRP and blood lactate were found to be risk factors for the recovery of patients with respiratory failure after esophagectomies. AME Publishing Company 2020-10 /pmc/articles/PMC8797711/ /pubmed/35117244 http://dx.doi.org/10.21037/tcr-20-1326a Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Su, Quanguan
Li, Huan
Yan, Honghong
Wei, Wenxiao
Liao, Wei
Ma, Gang
Prognostic risk factors for respiratory failure after esophagectomy
title Prognostic risk factors for respiratory failure after esophagectomy
title_full Prognostic risk factors for respiratory failure after esophagectomy
title_fullStr Prognostic risk factors for respiratory failure after esophagectomy
title_full_unstemmed Prognostic risk factors for respiratory failure after esophagectomy
title_short Prognostic risk factors for respiratory failure after esophagectomy
title_sort prognostic risk factors for respiratory failure after esophagectomy
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797711/
https://www.ncbi.nlm.nih.gov/pubmed/35117244
http://dx.doi.org/10.21037/tcr-20-1326a
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