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The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review
BACKGROUND: Worldwide, lung cancer has become the most common cancer type and lung cancer gradually becomes the leading cause of cancer death. MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer. This article will discuss the rate of miR-146 rs2910164 mutation...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797716/ https://www.ncbi.nlm.nih.gov/pubmed/35117288 http://dx.doi.org/10.21037/tcr-20-2171 |
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author | Zhang, Jun Shao, Weipeng Zhang, Zhenrong Liu, Deruo |
author_facet | Zhang, Jun Shao, Weipeng Zhang, Zhenrong Liu, Deruo |
author_sort | Zhang, Jun |
collection | PubMed |
description | BACKGROUND: Worldwide, lung cancer has become the most common cancer type and lung cancer gradually becomes the leading cause of cancer death. MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer. This article will discuss the rate of miR-146 rs2910164 mutation in lung cancer and normal people. METHODS: We searched the relevant published literature from January 1, 2009, to December 31, 2019, in English or Chinese, using the PubMed, Medline, Embase, China Biology Medicine disc, China National Knowledge Infrastructure, and WanFang databases. Two reviewers extracted data from eligible studies in duplicate with a standard data collection form and reached a consensus on each item. All analyses were performed using the Review Manager. RESULTS: In conclusion, the frequency of miR-146a GC genotype mutation in normal people and patients with lung cancer is 44% and 47% respectively and the rate of miR-146a CC genotype mutation in the normal people and patients with lung cancer is 17% and 22% respectively. What’s more, the frequency of miR-146a C allele mutation in normal people and patients with lung cancer is 40% and 46% respectively. CONCLUSIONS: In conclusion, we can find that the mutation rate of the lung cancer group is higher than the normal people. In the lung cancer group, we can find that the rate of mutation is highest in Italians and lowest in Indians, both in genotypes and in allele C, in which there are significant differences. Chinese and Koreans have similar mutation rates. |
format | Online Article Text |
id | pubmed-8797716 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87977162022-02-02 The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review Zhang, Jun Shao, Weipeng Zhang, Zhenrong Liu, Deruo Transl Cancer Res Original Article BACKGROUND: Worldwide, lung cancer has become the most common cancer type and lung cancer gradually becomes the leading cause of cancer death. MiR-146a rs2910164 polymorphism might be associated with the susceptibility to lung cancer. This article will discuss the rate of miR-146 rs2910164 mutation in lung cancer and normal people. METHODS: We searched the relevant published literature from January 1, 2009, to December 31, 2019, in English or Chinese, using the PubMed, Medline, Embase, China Biology Medicine disc, China National Knowledge Infrastructure, and WanFang databases. Two reviewers extracted data from eligible studies in duplicate with a standard data collection form and reached a consensus on each item. All analyses were performed using the Review Manager. RESULTS: In conclusion, the frequency of miR-146a GC genotype mutation in normal people and patients with lung cancer is 44% and 47% respectively and the rate of miR-146a CC genotype mutation in the normal people and patients with lung cancer is 17% and 22% respectively. What’s more, the frequency of miR-146a C allele mutation in normal people and patients with lung cancer is 40% and 46% respectively. CONCLUSIONS: In conclusion, we can find that the mutation rate of the lung cancer group is higher than the normal people. In the lung cancer group, we can find that the rate of mutation is highest in Italians and lowest in Indians, both in genotypes and in allele C, in which there are significant differences. Chinese and Koreans have similar mutation rates. AME Publishing Company 2020-11 /pmc/articles/PMC8797716/ /pubmed/35117288 http://dx.doi.org/10.21037/tcr-20-2171 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Article Zhang, Jun Shao, Weipeng Zhang, Zhenrong Liu, Deruo The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review |
title | The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review |
title_full | The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review |
title_fullStr | The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review |
title_full_unstemmed | The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review |
title_short | The rate of miR-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review |
title_sort | rate of mir-146a rs2910164 mutations in patients with lung cancer: a meta-analytic review |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797716/ https://www.ncbi.nlm.nih.gov/pubmed/35117288 http://dx.doi.org/10.21037/tcr-20-2171 |
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