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A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease

A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine that acts against IBD by scavenging proinflammatory cell-free DNA (cfDNA) and reac...

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Autores principales: Shi, Chengxin, Dawulieti, Jianati, Shi, Feiyu, Yang, Chao, Qin, Qian, Shi, Tongfei, Wang, Lizhao, Hu, Hanze, Sun, Madi, Ren, Li, Chen, Fangman, Zhao, Yawei, Liu, Feng, Li, Mingqiang, Mu, Lijun, Liu, Dan, Shao, Dan, Leong, Kam W., She, Junjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797786/
https://www.ncbi.nlm.nih.gov/pubmed/35089791
http://dx.doi.org/10.1126/sciadv.abj2372
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author Shi, Chengxin
Dawulieti, Jianati
Shi, Feiyu
Yang, Chao
Qin, Qian
Shi, Tongfei
Wang, Lizhao
Hu, Hanze
Sun, Madi
Ren, Li
Chen, Fangman
Zhao, Yawei
Liu, Feng
Li, Mingqiang
Mu, Lijun
Liu, Dan
Shao, Dan
Leong, Kam W.
She, Junjun
author_facet Shi, Chengxin
Dawulieti, Jianati
Shi, Feiyu
Yang, Chao
Qin, Qian
Shi, Tongfei
Wang, Lizhao
Hu, Hanze
Sun, Madi
Ren, Li
Chen, Fangman
Zhao, Yawei
Liu, Feng
Li, Mingqiang
Mu, Lijun
Liu, Dan
Shao, Dan
Leong, Kam W.
She, Junjun
author_sort Shi, Chengxin
collection PubMed
description A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine that acts against IBD by scavenging proinflammatory cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) to formulate nanoparticles (MON-PEI) that exhibited high cfDNA binding affinity and ROS-responsive degradation. In ulcerative colitis and Crohn’s disease mouse colitis models, orally administered MON-PEI accumulated preferentially in the inflamed colon and attenuated colonic and peritoneal inflammation by alleviating cfDNA- and ROS-mediated inflammatory responses, allowing a reduced dose frequency and ameliorating colitis even after delayed treatment. This work suggests a new nanomedicine strategy for IBD treatment.
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spelling pubmed-87977862022-02-09 A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease Shi, Chengxin Dawulieti, Jianati Shi, Feiyu Yang, Chao Qin, Qian Shi, Tongfei Wang, Lizhao Hu, Hanze Sun, Madi Ren, Li Chen, Fangman Zhao, Yawei Liu, Feng Li, Mingqiang Mu, Lijun Liu, Dan Shao, Dan Leong, Kam W. She, Junjun Sci Adv Biomedicine and Life Sciences A therapeutic strategy that targets multiple proinflammatory factors in inflammatory bowel disease (IBD) with minimal systemic side effects would be attractive. Here, we develop a drug-free, biodegradable nanomedicine that acts against IBD by scavenging proinflammatory cell-free DNA (cfDNA) and reactive oxygen species (ROS). Polyethylenimine (PEI) was conjugated to antioxidative diselenide-bridged mesoporous organosilica nanoparticles (MONs) to formulate nanoparticles (MON-PEI) that exhibited high cfDNA binding affinity and ROS-responsive degradation. In ulcerative colitis and Crohn’s disease mouse colitis models, orally administered MON-PEI accumulated preferentially in the inflamed colon and attenuated colonic and peritoneal inflammation by alleviating cfDNA- and ROS-mediated inflammatory responses, allowing a reduced dose frequency and ameliorating colitis even after delayed treatment. This work suggests a new nanomedicine strategy for IBD treatment. American Association for the Advancement of Science 2022-01-28 /pmc/articles/PMC8797786/ /pubmed/35089791 http://dx.doi.org/10.1126/sciadv.abj2372 Text en Copyright © 2022 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Distributed under a Creative Commons Attribution NonCommercial License 4.0 (CC BY-NC). https://creativecommons.org/licenses/by-nc/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution-NonCommercial license (https://creativecommons.org/licenses/by-nc/4.0/) , which permits use, distribution, and reproduction in any medium, so long as the resultant use is not for commercial advantage and provided the original work is properly cited.
spellingShingle Biomedicine and Life Sciences
Shi, Chengxin
Dawulieti, Jianati
Shi, Feiyu
Yang, Chao
Qin, Qian
Shi, Tongfei
Wang, Lizhao
Hu, Hanze
Sun, Madi
Ren, Li
Chen, Fangman
Zhao, Yawei
Liu, Feng
Li, Mingqiang
Mu, Lijun
Liu, Dan
Shao, Dan
Leong, Kam W.
She, Junjun
A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
title A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
title_full A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
title_fullStr A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
title_full_unstemmed A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
title_short A nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
title_sort nanoparticulate dual scavenger for targeted therapy of inflammatory bowel disease
topic Biomedicine and Life Sciences
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797786/
https://www.ncbi.nlm.nih.gov/pubmed/35089791
http://dx.doi.org/10.1126/sciadv.abj2372
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