Inhibition of sphingolipid de novo synthesis counteracts muscular dystrophy

Duchenne muscular dystrophy (DMD), the most common muscular dystrophy, is a severe muscle disorder, causing muscle weakness, loss of independence, and premature death. Here, we establish the link between sphingolipids and muscular dystrophy. Transcripts of sphingolipid de novo biosynthesis pathway a...

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Detalles Bibliográficos
Autores principales: Laurila, Pirkka-Pekka, Luan, Peiling, Wohlwend, Martin, Zanou, Nadège, Crisol, Barbara, Imamura de Lima, Tanes, Goeminne, Ludger J. E., Gallart-Ayala, Hector, Shong, Minho, Ivanisevic, Julijana, Place, Nicolas, Auwerx, Johan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797791/
https://www.ncbi.nlm.nih.gov/pubmed/35089797
http://dx.doi.org/10.1126/sciadv.abh4423

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