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Long non-coding RNAs regulating multiple proliferative pathways in cancer cell
Long non-coding RNAs (lncRNAs) belong to an extremely heterogeneous class of non-coding RNAs with a length ranging from 200 to 100,000 bp. They modulate a series of cellular pathways in both physiological and pathological context. It is no coincidence that they are expressed in an aberrant way in pa...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797882/ https://www.ncbi.nlm.nih.gov/pubmed/35116622 http://dx.doi.org/10.21037/tcr-21-230 |
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author | De Martino, Marco Esposito, Francesco Pallante, Pierlorenzo |
author_facet | De Martino, Marco Esposito, Francesco Pallante, Pierlorenzo |
author_sort | De Martino, Marco |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) belong to an extremely heterogeneous class of non-coding RNAs with a length ranging from 200 to 100,000 bp. They modulate a series of cellular pathways in both physiological and pathological context. It is no coincidence that they are expressed in an aberrant way in pathologies such as cancer, so as to deserve to be subclassified as oncogenes or tumor suppressors. These molecules are also involved in the regulation of cancer cell proliferation. Several lncRNAs are able to modulate cell growth both positively and negatively, and in this review we have focused on a small group of them, characterized by the simultaneous action on different pathways regulating cell proliferation. They have been considered in the light of their behavior in three different subtypes of proliferative pathways that we can define as (I) tumor suppressor, (II) oncogenic and (III) transcriptionally-driven. More specifically, we have characterized some lncRNAs considered oncogenes (such as H19, linc-ROR, MALAT1, HULC, HOTAIR and ANRIL), tumor suppressors (such as MEG3 and lincRNA-p21), and both oncogenes/tumor suppressors (UCA1 and TUG1) in a little more detail. As can be understood from the review, the interactions between lncRNAs and their molecular targets, only in the context of controlling cell proliferation, give rise to an intricate molecular network, the understanding of which, in the future, will certainly be of help for the treatment of molecular diseases such as cancer. |
format | Online Article Text |
id | pubmed-8797882 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87978822022-02-02 Long non-coding RNAs regulating multiple proliferative pathways in cancer cell De Martino, Marco Esposito, Francesco Pallante, Pierlorenzo Transl Cancer Res Review Article on Clinic and Therapeutic Potential of Non-coding RNAs in Cancer Long non-coding RNAs (lncRNAs) belong to an extremely heterogeneous class of non-coding RNAs with a length ranging from 200 to 100,000 bp. They modulate a series of cellular pathways in both physiological and pathological context. It is no coincidence that they are expressed in an aberrant way in pathologies such as cancer, so as to deserve to be subclassified as oncogenes or tumor suppressors. These molecules are also involved in the regulation of cancer cell proliferation. Several lncRNAs are able to modulate cell growth both positively and negatively, and in this review we have focused on a small group of them, characterized by the simultaneous action on different pathways regulating cell proliferation. They have been considered in the light of their behavior in three different subtypes of proliferative pathways that we can define as (I) tumor suppressor, (II) oncogenic and (III) transcriptionally-driven. More specifically, we have characterized some lncRNAs considered oncogenes (such as H19, linc-ROR, MALAT1, HULC, HOTAIR and ANRIL), tumor suppressors (such as MEG3 and lincRNA-p21), and both oncogenes/tumor suppressors (UCA1 and TUG1) in a little more detail. As can be understood from the review, the interactions between lncRNAs and their molecular targets, only in the context of controlling cell proliferation, give rise to an intricate molecular network, the understanding of which, in the future, will certainly be of help for the treatment of molecular diseases such as cancer. AME Publishing Company 2021-06 /pmc/articles/PMC8797882/ /pubmed/35116622 http://dx.doi.org/10.21037/tcr-21-230 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Review Article on Clinic and Therapeutic Potential of Non-coding RNAs in Cancer De Martino, Marco Esposito, Francesco Pallante, Pierlorenzo Long non-coding RNAs regulating multiple proliferative pathways in cancer cell |
title | Long non-coding RNAs regulating multiple proliferative pathways in cancer cell |
title_full | Long non-coding RNAs regulating multiple proliferative pathways in cancer cell |
title_fullStr | Long non-coding RNAs regulating multiple proliferative pathways in cancer cell |
title_full_unstemmed | Long non-coding RNAs regulating multiple proliferative pathways in cancer cell |
title_short | Long non-coding RNAs regulating multiple proliferative pathways in cancer cell |
title_sort | long non-coding rnas regulating multiple proliferative pathways in cancer cell |
topic | Review Article on Clinic and Therapeutic Potential of Non-coding RNAs in Cancer |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797882/ https://www.ncbi.nlm.nih.gov/pubmed/35116622 http://dx.doi.org/10.21037/tcr-21-230 |
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