Cargando…

Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis

BACKGROUND: Circulating microRNAs are novel diagnostic markers for various types of cancer. Several studies have investigated the diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma (MPM), but the results varied. Therefore, we performed a systematic review and meta-analysis...

Descripción completa

Detalles Bibliográficos
Autores principales: Zhang, Lei, Zhou, Qianghua, Han, Yan-Qiu, Li, Peng, Ouyang, Pei-Heng, Wang, Mei-Ying, Hu, Zhi-De
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797892/
https://www.ncbi.nlm.nih.gov/pubmed/35116507
http://dx.doi.org/10.21037/tcr-21-104
_version_ 1784641663124111360
author Zhang, Lei
Zhou, Qianghua
Han, Yan-Qiu
Li, Peng
Ouyang, Pei-Heng
Wang, Mei-Ying
Hu, Zhi-De
author_facet Zhang, Lei
Zhou, Qianghua
Han, Yan-Qiu
Li, Peng
Ouyang, Pei-Heng
Wang, Mei-Ying
Hu, Zhi-De
author_sort Zhang, Lei
collection PubMed
description BACKGROUND: Circulating microRNAs are novel diagnostic markers for various types of cancer. Several studies have investigated the diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma (MPM), but the results varied. Therefore, we performed a systematic review and meta-analysis to investigate the diagnostic value of circulating miR-126 for MPM. METHODS: The PubMed database was searched to identify potentially eligible studies published before October 2020. The studies investigating the diagnostic value of circulating miR-126 for MPM were included in a systematic review and meta-analysis. A bivariate model was used to pool eligible studies’ sensitivity and specificity. The revised tool for the quality assessment of diagnostic accuracy studies (QUADAS-2) was used to assess eligible studies’ quality. RESULTS: Four studies with 156 MPM patients and 459 controls were included in this systematic review and meta-analysis. The pooled diagnostic sensitivity and specificity of circulating miR-126 for MPM were 0.71 and 0.69, respectively. A high risk of bias was observed in the domains of patient selection, index test, and flow and timing. CONCLUSIONS: Circulating miR-126 has limited value for diagnosing MPM. Considering that the available studies have a high risk of bias, further rigorous studies are needed to assess the diagnostic value of circulating miR-126 for MPM.
format Online
Article
Text
id pubmed-8797892
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher AME Publishing Company
record_format MEDLINE/PubMed
spelling pubmed-87978922022-02-02 Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis Zhang, Lei Zhou, Qianghua Han, Yan-Qiu Li, Peng Ouyang, Pei-Heng Wang, Mei-Ying Hu, Zhi-De Transl Cancer Res Original Article BACKGROUND: Circulating microRNAs are novel diagnostic markers for various types of cancer. Several studies have investigated the diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma (MPM), but the results varied. Therefore, we performed a systematic review and meta-analysis to investigate the diagnostic value of circulating miR-126 for MPM. METHODS: The PubMed database was searched to identify potentially eligible studies published before October 2020. The studies investigating the diagnostic value of circulating miR-126 for MPM were included in a systematic review and meta-analysis. A bivariate model was used to pool eligible studies’ sensitivity and specificity. The revised tool for the quality assessment of diagnostic accuracy studies (QUADAS-2) was used to assess eligible studies’ quality. RESULTS: Four studies with 156 MPM patients and 459 controls were included in this systematic review and meta-analysis. The pooled diagnostic sensitivity and specificity of circulating miR-126 for MPM were 0.71 and 0.69, respectively. A high risk of bias was observed in the domains of patient selection, index test, and flow and timing. CONCLUSIONS: Circulating miR-126 has limited value for diagnosing MPM. Considering that the available studies have a high risk of bias, further rigorous studies are needed to assess the diagnostic value of circulating miR-126 for MPM. AME Publishing Company 2021-04 /pmc/articles/PMC8797892/ /pubmed/35116507 http://dx.doi.org/10.21037/tcr-21-104 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Zhang, Lei
Zhou, Qianghua
Han, Yan-Qiu
Li, Peng
Ouyang, Pei-Heng
Wang, Mei-Ying
Hu, Zhi-De
Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis
title Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis
title_full Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis
title_fullStr Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis
title_full_unstemmed Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis
title_short Diagnostic accuracy of circulating miR-126 for malignant pleural mesothelioma: a systematic review and meta-analysis
title_sort diagnostic accuracy of circulating mir-126 for malignant pleural mesothelioma: a systematic review and meta-analysis
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797892/
https://www.ncbi.nlm.nih.gov/pubmed/35116507
http://dx.doi.org/10.21037/tcr-21-104
work_keys_str_mv AT zhanglei diagnosticaccuracyofcirculatingmir126formalignantpleuralmesotheliomaasystematicreviewandmetaanalysis
AT zhouqianghua diagnosticaccuracyofcirculatingmir126formalignantpleuralmesotheliomaasystematicreviewandmetaanalysis
AT hanyanqiu diagnosticaccuracyofcirculatingmir126formalignantpleuralmesotheliomaasystematicreviewandmetaanalysis
AT lipeng diagnosticaccuracyofcirculatingmir126formalignantpleuralmesotheliomaasystematicreviewandmetaanalysis
AT ouyangpeiheng diagnosticaccuracyofcirculatingmir126formalignantpleuralmesotheliomaasystematicreviewandmetaanalysis
AT wangmeiying diagnosticaccuracyofcirculatingmir126formalignantpleuralmesotheliomaasystematicreviewandmetaanalysis
AT huzhide diagnosticaccuracyofcirculatingmir126formalignantpleuralmesotheliomaasystematicreviewandmetaanalysis