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Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis
BACKGROUND: The short-term clinical outcomes between early enteral nutrition (EEN) and total parenteral nutrition (TPN) after pancreaticoduodenectomy (PD) for pancreatic cancer were not clear. METHODS: We searched the PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI) a...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797909/ https://www.ncbi.nlm.nih.gov/pubmed/35116883 http://dx.doi.org/10.21037/tcr.2019.07.47 |
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author | Kang, Yi-Kun Dong, Li Ge, Yang An, Guang-Yu |
author_facet | Kang, Yi-Kun Dong, Li Ge, Yang An, Guang-Yu |
author_sort | Kang, Yi-Kun |
collection | PubMed |
description | BACKGROUND: The short-term clinical outcomes between early enteral nutrition (EEN) and total parenteral nutrition (TPN) after pancreaticoduodenectomy (PD) for pancreatic cancer were not clear. METHODS: We searched the PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases to identify randomized controlled studies comparing EEN and TPN after PD for pancreatic cancer. Then a meta-analysis was conducted. RESULTS: Seven studies with 486 patients were included in the analysis. After surgery, patients in EEN group had higher level of plasma total protein (TP) [weighted mean difference (WMD): 1.83, 95% confidence interval (CI): 0.33–3.32, P=0.02], while the albumin (ALB) level was similar between the two groups (WMD: 0.25, 95% CI: –4.07–4.56, P=0.91). As for the bowel function, EEN group had shorter exhaust time (WMD: –0.66, 95% CI: –0.81 to –0.51, P<0.001) and bowel movement time (WMD: –2.27, 95% CI: –2.61 to –1.94, P<0.001) than TPN group. EEN group also had lower short-term total complication rate [relative risk (RR): 0.68, 95% CI: 0.51–0.92, P=0.01] and postoperative hemorrhage rate (RR: 0.22, 95% CI: 0.06–0.75, P=0.02), while there was no significant difference in infection rate (RR: 0.68, 95% CI: 0.38–1.22, P=0.20), pancreatic fistula rate (RR: 0.63, 95% CI: 0.35–1.16, P=0.14) and delayed gastric emptying (DGE) rate (RR: 0.72, 95% CI: 0.39–1.33, P=0.29) between the groups. In addition, EEN group had shorter hospital stay (WMD: –1.53, 95% CI: –2.12 to –0.94, P<0.001). CONCLUSIONS: Compared to TPN, EEN showed better outcomes in improving the nutritional status and bowel function as well as decreasing complication rate and hospital stay after PD in patients with pancreatic cancer. |
format | Online Article Text |
id | pubmed-8797909 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87979092022-02-02 Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis Kang, Yi-Kun Dong, Li Ge, Yang An, Guang-Yu Transl Cancer Res Original Article BACKGROUND: The short-term clinical outcomes between early enteral nutrition (EEN) and total parenteral nutrition (TPN) after pancreaticoduodenectomy (PD) for pancreatic cancer were not clear. METHODS: We searched the PubMed, Embase, Web of Science, Chinese National Knowledge Infrastructure (CNKI) and Wanfang databases to identify randomized controlled studies comparing EEN and TPN after PD for pancreatic cancer. Then a meta-analysis was conducted. RESULTS: Seven studies with 486 patients were included in the analysis. After surgery, patients in EEN group had higher level of plasma total protein (TP) [weighted mean difference (WMD): 1.83, 95% confidence interval (CI): 0.33–3.32, P=0.02], while the albumin (ALB) level was similar between the two groups (WMD: 0.25, 95% CI: –4.07–4.56, P=0.91). As for the bowel function, EEN group had shorter exhaust time (WMD: –0.66, 95% CI: –0.81 to –0.51, P<0.001) and bowel movement time (WMD: –2.27, 95% CI: –2.61 to –1.94, P<0.001) than TPN group. EEN group also had lower short-term total complication rate [relative risk (RR): 0.68, 95% CI: 0.51–0.92, P=0.01] and postoperative hemorrhage rate (RR: 0.22, 95% CI: 0.06–0.75, P=0.02), while there was no significant difference in infection rate (RR: 0.68, 95% CI: 0.38–1.22, P=0.20), pancreatic fistula rate (RR: 0.63, 95% CI: 0.35–1.16, P=0.14) and delayed gastric emptying (DGE) rate (RR: 0.72, 95% CI: 0.39–1.33, P=0.29) between the groups. In addition, EEN group had shorter hospital stay (WMD: –1.53, 95% CI: –2.12 to –0.94, P<0.001). CONCLUSIONS: Compared to TPN, EEN showed better outcomes in improving the nutritional status and bowel function as well as decreasing complication rate and hospital stay after PD in patients with pancreatic cancer. AME Publishing Company 2019-08 /pmc/articles/PMC8797909/ /pubmed/35116883 http://dx.doi.org/10.21037/tcr.2019.07.47 Text en 2019 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Article Kang, Yi-Kun Dong, Li Ge, Yang An, Guang-Yu Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis |
title | Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis |
title_full | Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis |
title_fullStr | Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis |
title_full_unstemmed | Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis |
title_short | Short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis |
title_sort | short-term clinical outcomes of enteral nutrition versus parenteral nutrition after surgery for pancreatic cancer: a meta-analysis |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797909/ https://www.ncbi.nlm.nih.gov/pubmed/35116883 http://dx.doi.org/10.21037/tcr.2019.07.47 |
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