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Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients
BACKGROUND: The present study was conducted to explore the prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients. METHODS: Totally 200 gastric cancer patients who underwent surgical resection were enrolled and their Hospital Anxiety and Depression...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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AME Publishing Company
2020
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797988/ https://www.ncbi.nlm.nih.gov/pubmed/35117485 http://dx.doi.org/10.21037/tcr.2020.01.11 |
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author | Han, Lijuan |
author_facet | Han, Lijuan |
author_sort | Han, Lijuan |
collection | PubMed |
description | BACKGROUND: The present study was conducted to explore the prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients. METHODS: Totally 200 gastric cancer patients who underwent surgical resection were enrolled and their Hospital Anxiety and Depression Scale (HADS) scores were assessed before surgery. Besides, 200 healthy controls were enrolled with their HADS scores assessed at enrollment. RESULTS: The HADS-anxiety score (7.4±3.8 vs. 4.7±2.8, P<0.001), prevalence (42.5% vs. 13.5%, P<0.001) and severity (P=0.002) of anxiety were greatly increased in gastric cancer patients compared with healthy controls. And HADS-depression score (6.9±3.5 vs. 4.2±2.6, P<0.001), prevalence (33.5% vs. 10.0%, P<0.001) and severity (P=0.001) of depression were also dramatically elevated in gastric cancer patients compared with healthy controls. Regarding the factors predicting anxiety/depression risks in gastric cancer patients, gender (female) (P=0.003), diabetes (P<0.001), higher pathological grade (P=0.005), larger tumor size (P=0.044) and higher T stage (P=0.017) were independent predictive factors for higher risk of anxiety, and age (>60 years) (P=0.025), gender (female) (P=0.004), hyperlipidemia (P=0.039), diabetes (P<0.001) and higher TNM stage (P=0.003) were independent predictive factors for higher risk of depression. Most importantly, anxiety/depression and the severity of anxiety/depression were all negatively associated with disease-free survival as well as overall survival (all P<0.05) in surgical gastric cancer patients. CONCLUSIONS: Anxiety/depression are common and severe, which predicts unfavorable prognosis in gastric cancer patients underwent surgery, suggesting the necessity of psychological care post-surgery. |
format | Online Article Text |
id | pubmed-8797988 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87979882022-02-02 Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients Han, Lijuan Transl Cancer Res Original Article BACKGROUND: The present study was conducted to explore the prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients. METHODS: Totally 200 gastric cancer patients who underwent surgical resection were enrolled and their Hospital Anxiety and Depression Scale (HADS) scores were assessed before surgery. Besides, 200 healthy controls were enrolled with their HADS scores assessed at enrollment. RESULTS: The HADS-anxiety score (7.4±3.8 vs. 4.7±2.8, P<0.001), prevalence (42.5% vs. 13.5%, P<0.001) and severity (P=0.002) of anxiety were greatly increased in gastric cancer patients compared with healthy controls. And HADS-depression score (6.9±3.5 vs. 4.2±2.6, P<0.001), prevalence (33.5% vs. 10.0%, P<0.001) and severity (P=0.001) of depression were also dramatically elevated in gastric cancer patients compared with healthy controls. Regarding the factors predicting anxiety/depression risks in gastric cancer patients, gender (female) (P=0.003), diabetes (P<0.001), higher pathological grade (P=0.005), larger tumor size (P=0.044) and higher T stage (P=0.017) were independent predictive factors for higher risk of anxiety, and age (>60 years) (P=0.025), gender (female) (P=0.004), hyperlipidemia (P=0.039), diabetes (P<0.001) and higher TNM stage (P=0.003) were independent predictive factors for higher risk of depression. Most importantly, anxiety/depression and the severity of anxiety/depression were all negatively associated with disease-free survival as well as overall survival (all P<0.05) in surgical gastric cancer patients. CONCLUSIONS: Anxiety/depression are common and severe, which predicts unfavorable prognosis in gastric cancer patients underwent surgery, suggesting the necessity of psychological care post-surgery. AME Publishing Company 2020-03 /pmc/articles/PMC8797988/ /pubmed/35117485 http://dx.doi.org/10.21037/tcr.2020.01.11 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Article Han, Lijuan Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients |
title | Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients |
title_full | Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients |
title_fullStr | Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients |
title_full_unstemmed | Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients |
title_short | Prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients |
title_sort | prevalence, risk factors and prognostic role of anxiety and depression in surgical gastric cancer patients |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8797988/ https://www.ncbi.nlm.nih.gov/pubmed/35117485 http://dx.doi.org/10.21037/tcr.2020.01.11 |
work_keys_str_mv | AT hanlijuan prevalenceriskfactorsandprognosticroleofanxietyanddepressioninsurgicalgastriccancerpatients |