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Inhibition of osteopontin overcomes acquired resistance to afatinib in EGFR-mutant non-small-cell lung cancer

BACKGROUND: We aimed to explore a novel therapeutic strategy to conquer acquired resistance to second generation EGFR-TKI afatinib in EGFR-mutant NSCLC. METHODS: Firstly, we established afatinib-resistant cell lines using increasing concentrations of afatinib. Secondly, we over-expressed or silenced...

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Detalles Bibliográficos
Autores principales:	Zhang, Hongye, Wang, Ruiyu, Wang, Mingxia, Luo, Judong, Liu, Changmin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798064/ https://www.ncbi.nlm.nih.gov/pubmed/35117421 http://dx.doi.org/10.21037/tcr.2019.12.49

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