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Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor

BACKGROUND: The clinicopathological features and prognostic factors of primary clear cell carcinoma of the liver (PCCCL) remain unknown for the rarity. We aimed to determine the clinical and therapeutic characteristics of PCCCL and the effects of these factors on the prognosis. METHODS: Patients wer...

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Autores principales: Wen, Jie, Yao, Xueyan, Xue, Lixiang, Aili, Abudureyimujiang, Wang, Junjie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798129/
https://www.ncbi.nlm.nih.gov/pubmed/35116639
http://dx.doi.org/10.21037/tcr-21-9
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author Wen, Jie
Yao, Xueyan
Xue, Lixiang
Aili, Abudureyimujiang
Wang, Junjie
author_facet Wen, Jie
Yao, Xueyan
Xue, Lixiang
Aili, Abudureyimujiang
Wang, Junjie
author_sort Wen, Jie
collection PubMed
description BACKGROUND: The clinicopathological features and prognostic factors of primary clear cell carcinoma of the liver (PCCCL) remain unknown for the rarity. We aimed to determine the clinical and therapeutic characteristics of PCCCL and the effects of these factors on the prognosis. METHODS: Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Data were analyzed with the Kaplan-Meier, Cox proportional hazards regression analyses and the multivariable competing risk model. RESULTS: We included 223 PCCCL patients and the majority of them had an age under 75 years (82.5%). Most patients were white people (63.2%). The patients diagnosed at localized stage (63.7%), T1 (49.8%), N0 (96.0%), M0 (87.4%) and American Joint Committee on Cancer (AJCC) I (44.4%) made up the majority of the population. More PCCCL tumors had a size beneath 4 cm (74.9%) and no vascular invasion (63.2%). The 3-, 5-, and 10-year overall survival (OS) probabilities and disease-specific survival (DSS) rates were 35.8%, 24.3%, 14.4%, and 41.6%, 29.4%, 22.2%, respectively. The patients with tumor ≥1 cm [OS, hazard ratio (HR) =1.822; DSS, HR =1.959] had a higher risk of death than those patients with tumor <1 cm. Among surgical means, hepatectomy (OS, HR =0.070; DSS, HR =0.050) and total hepatectomy plus transplant (OS, HR =0.074; DSS, HR =0.065) were more beneficial to PCCCL. CONCLUSIONS: PCCCL patients were inclined to be young, white people-prevalent, localized and early. PCCCL tend to had a slow growth and be weakly aggressive. However, comparing with previous reports, we found that PCCCL had a relatively poor outcome. Tumor size and surgery were the independent prognostic factors for OS and DSS.
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spelling pubmed-87981292022-02-02 Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor Wen, Jie Yao, Xueyan Xue, Lixiang Aili, Abudureyimujiang Wang, Junjie Transl Cancer Res Original Article BACKGROUND: The clinicopathological features and prognostic factors of primary clear cell carcinoma of the liver (PCCCL) remain unknown for the rarity. We aimed to determine the clinical and therapeutic characteristics of PCCCL and the effects of these factors on the prognosis. METHODS: Patients were selected from the Surveillance, Epidemiology, and End Results (SEER) database. Data were analyzed with the Kaplan-Meier, Cox proportional hazards regression analyses and the multivariable competing risk model. RESULTS: We included 223 PCCCL patients and the majority of them had an age under 75 years (82.5%). Most patients were white people (63.2%). The patients diagnosed at localized stage (63.7%), T1 (49.8%), N0 (96.0%), M0 (87.4%) and American Joint Committee on Cancer (AJCC) I (44.4%) made up the majority of the population. More PCCCL tumors had a size beneath 4 cm (74.9%) and no vascular invasion (63.2%). The 3-, 5-, and 10-year overall survival (OS) probabilities and disease-specific survival (DSS) rates were 35.8%, 24.3%, 14.4%, and 41.6%, 29.4%, 22.2%, respectively. The patients with tumor ≥1 cm [OS, hazard ratio (HR) =1.822; DSS, HR =1.959] had a higher risk of death than those patients with tumor <1 cm. Among surgical means, hepatectomy (OS, HR =0.070; DSS, HR =0.050) and total hepatectomy plus transplant (OS, HR =0.074; DSS, HR =0.065) were more beneficial to PCCCL. CONCLUSIONS: PCCCL patients were inclined to be young, white people-prevalent, localized and early. PCCCL tend to had a slow growth and be weakly aggressive. However, comparing with previous reports, we found that PCCCL had a relatively poor outcome. Tumor size and surgery were the independent prognostic factors for OS and DSS. AME Publishing Company 2021-07 /pmc/articles/PMC8798129/ /pubmed/35116639 http://dx.doi.org/10.21037/tcr-21-9 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Wen, Jie
Yao, Xueyan
Xue, Lixiang
Aili, Abudureyimujiang
Wang, Junjie
Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
title Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
title_full Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
title_fullStr Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
title_full_unstemmed Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
title_short Predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
title_sort predictors and survival of primary clear cell carcinoma of liver: a population-based study of an uncommon primary liver tumor
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798129/
https://www.ncbi.nlm.nih.gov/pubmed/35116639
http://dx.doi.org/10.21037/tcr-21-9
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