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Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity
BACKGROUND: As a novel cancer stem cell marker, the biological functions of aldehyde dehydrogenases (ALDH enzymes) are a hot topic in current cancer research. However, there is a lack of systematic understanding of ALDH enzymes, which has hindered the translation of targeted therapies from bench wor...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798302/ https://www.ncbi.nlm.nih.gov/pubmed/35116357 http://dx.doi.org/10.21037/tcr-21-1160 |
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author | Wang, Di Jiang, Haoyu Wang, Zhiliang Huang, Ruoyu Jiang, Tao Kahlert, Ulf Dietrich Li, Guanzhang Zhang, Wei |
author_facet | Wang, Di Jiang, Haoyu Wang, Zhiliang Huang, Ruoyu Jiang, Tao Kahlert, Ulf Dietrich Li, Guanzhang Zhang, Wei |
author_sort | Wang, Di |
collection | PubMed |
description | BACKGROUND: As a novel cancer stem cell marker, the biological functions of aldehyde dehydrogenases (ALDH enzymes) are a hot topic in current cancer research. However, there is a lack of systematic understanding of ALDH enzymes, which has hindered the translation of targeted therapies from bench work into the clinic. METHODS: Based on transcriptome data from 999 glioma patients, functional clustering analysis was performed to reveal the functional phenotypes of ALDH isoforms. Subsequently, ALDH subgroups closely related to gliomas were identified by Cox survival analysis. Finally, gene set variation analysis (GSVA) and Pearson correlation analysis were used to explore the biological functions of ALDH enzymes. RESULTS: Our study found that ALDH enzymes could be classified into 5 subgroups, among which 3 groups were closely related to malignant progression and the prognosis of gliomas. We found that ALDH enzymes were closely related to gene mutations, which were most likely caused by changes in DNA repair functions. Further studies revealed that ALDH enzymes affect tumor immune functions, especially the expression of immune checkpoints. The effectiveness of immune checkpoint inhibitors in treating glioma might be improved by altering the expression of ALDH enzymes in specific subgroups. CONCLUSIONS: This study comprehensively revealed the biological functions of ALDH enzymes in glioma and provided details about the potential clinical application of targeted therapy for ALDH enzymes. |
format | Online Article Text |
id | pubmed-8798302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87983022022-02-02 Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity Wang, Di Jiang, Haoyu Wang, Zhiliang Huang, Ruoyu Jiang, Tao Kahlert, Ulf Dietrich Li, Guanzhang Zhang, Wei Transl Cancer Res Original Article BACKGROUND: As a novel cancer stem cell marker, the biological functions of aldehyde dehydrogenases (ALDH enzymes) are a hot topic in current cancer research. However, there is a lack of systematic understanding of ALDH enzymes, which has hindered the translation of targeted therapies from bench work into the clinic. METHODS: Based on transcriptome data from 999 glioma patients, functional clustering analysis was performed to reveal the functional phenotypes of ALDH isoforms. Subsequently, ALDH subgroups closely related to gliomas were identified by Cox survival analysis. Finally, gene set variation analysis (GSVA) and Pearson correlation analysis were used to explore the biological functions of ALDH enzymes. RESULTS: Our study found that ALDH enzymes could be classified into 5 subgroups, among which 3 groups were closely related to malignant progression and the prognosis of gliomas. We found that ALDH enzymes were closely related to gene mutations, which were most likely caused by changes in DNA repair functions. Further studies revealed that ALDH enzymes affect tumor immune functions, especially the expression of immune checkpoints. The effectiveness of immune checkpoint inhibitors in treating glioma might be improved by altering the expression of ALDH enzymes in specific subgroups. CONCLUSIONS: This study comprehensively revealed the biological functions of ALDH enzymes in glioma and provided details about the potential clinical application of targeted therapy for ALDH enzymes. AME Publishing Company 2021-12 /pmc/articles/PMC8798302/ /pubmed/35116357 http://dx.doi.org/10.21037/tcr-21-1160 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Article Wang, Di Jiang, Haoyu Wang, Zhiliang Huang, Ruoyu Jiang, Tao Kahlert, Ulf Dietrich Li, Guanzhang Zhang, Wei Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity |
title | Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity |
title_full | Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity |
title_fullStr | Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity |
title_full_unstemmed | Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity |
title_short | Functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity |
title_sort | functional clustering analysis identifies specific subtypes of aldehyde dehydrogenase associated with glioma immunity |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798302/ https://www.ncbi.nlm.nih.gov/pubmed/35116357 http://dx.doi.org/10.21037/tcr-21-1160 |
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