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Mutation of PD-1 immune receptor tyrosine-based switch motif (ITSM) enhances the antitumor activity of cytotoxic T cells

BACKGROUND: Programmed cell death protein 1 (PD-1), as an immune checkpoint cell membrane receptor, negatively regulates T cell activation via its immune receptor, the tyrosine-based switch motif (ITSM). The purpose of this research was to evaluate the antitumor activity T cells with the ITSM mutati...

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Detalles Bibliográficos
Autores principales:	Qi, Tongbing, Fu, Juan, Zhang, Wen, Cui, Weitong, Xu, Xiaosong, Yue, Jianmei, Wang, Qinglu, Tian, Xuewen
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798335/ https://www.ncbi.nlm.nih.gov/pubmed/35117290 http://dx.doi.org/10.21037/tcr-20-2118

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