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Effects of a combined treatment regimen consisting of Hsp90 inhibitor DS-2248 and radiation in vitro and in a tumor mouse model

BACKGROUND: Heat shock protein 90 (HSP90) is a molecular chaperone that is responsible for the conformational maintenance of several client proteins that play important roles in DNA damage repair, apoptosis following radiation, and resistance to radiation therapy. DS-2248 (tricyclic pyrazolopyrimidi...

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Detalles Bibliográficos
Autores principales:	Kondo, Takuhito, Shibamoto, Yuta, Kawai, Tatsuya, Sugie, Chikao, Wang, Zhen, Nakamura, Koichi, Murai, Taro, Manabe, Yoshihiko, Nakashima, Masahiro, Matsuo, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798455/ https://www.ncbi.nlm.nih.gov/pubmed/35116587 http://dx.doi.org/10.21037/tcr-21-71

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