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Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients

BACKGROUND: This study aims to discuss the application value of serum cystatin C (Cys C) in detecting early renal function injury in elderly patients with malignant tumors after chemotherapy. METHODS: The data at different chemotherapy time points (before chemotherapy, after two cycles of chemothera...

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Autores principales: Li, Wen-Hui, Yu, Xue-Jun, Lin, Qiu-Ju, Cheng, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798458/
https://www.ncbi.nlm.nih.gov/pubmed/35117579
http://dx.doi.org/10.21037/tcr.2020.03.30
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author Li, Wen-Hui
Yu, Xue-Jun
Lin, Qiu-Ju
Cheng, Xin
author_facet Li, Wen-Hui
Yu, Xue-Jun
Lin, Qiu-Ju
Cheng, Xin
author_sort Li, Wen-Hui
collection PubMed
description BACKGROUND: This study aims to discuss the application value of serum cystatin C (Cys C) in detecting early renal function injury in elderly patients with malignant tumors after chemotherapy. METHODS: The data at different chemotherapy time points (before chemotherapy, after two cycles of chemotherapy, and after four cycles of chemotherapy) were analyzed. RESULTS: Serum Cys C was significantly higher after chemotherapy than before chemotherapy in elderly patients with malignant tumors, and the endogenous creatinine clearance rate (CCr) significantly decreased. These were significantly correlated. However, there was no significant change in serum creatinine (SCr) and blood urea nitrogen (BUN). Cys C continued to increase with the prolonged time of chemotherapy. In addition, Cys C was sensitive for detecting renal impairment caused by platinum-based chemotherapy drugs. CONCLUSIONS: The diagnostic effect of Cys C on early renal function injury after chemotherapy in elderly patients with malignant tumors is better, when compared to traditional renal function test items, such as SCr, BUN and CCr.
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spelling pubmed-87984582022-02-02 Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients Li, Wen-Hui Yu, Xue-Jun Lin, Qiu-Ju Cheng, Xin Transl Cancer Res Original Article BACKGROUND: This study aims to discuss the application value of serum cystatin C (Cys C) in detecting early renal function injury in elderly patients with malignant tumors after chemotherapy. METHODS: The data at different chemotherapy time points (before chemotherapy, after two cycles of chemotherapy, and after four cycles of chemotherapy) were analyzed. RESULTS: Serum Cys C was significantly higher after chemotherapy than before chemotherapy in elderly patients with malignant tumors, and the endogenous creatinine clearance rate (CCr) significantly decreased. These were significantly correlated. However, there was no significant change in serum creatinine (SCr) and blood urea nitrogen (BUN). Cys C continued to increase with the prolonged time of chemotherapy. In addition, Cys C was sensitive for detecting renal impairment caused by platinum-based chemotherapy drugs. CONCLUSIONS: The diagnostic effect of Cys C on early renal function injury after chemotherapy in elderly patients with malignant tumors is better, when compared to traditional renal function test items, such as SCr, BUN and CCr. AME Publishing Company 2020-04 /pmc/articles/PMC8798458/ /pubmed/35117579 http://dx.doi.org/10.21037/tcr.2020.03.30 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Li, Wen-Hui
Yu, Xue-Jun
Lin, Qiu-Ju
Cheng, Xin
Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients
title Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients
title_full Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients
title_fullStr Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients
title_full_unstemmed Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients
title_short Clinical significance of serum cystatin C in early evaluation of renal impairment caused by chemotherapy in elderly patients
title_sort clinical significance of serum cystatin c in early evaluation of renal impairment caused by chemotherapy in elderly patients
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798458/
https://www.ncbi.nlm.nih.gov/pubmed/35117579
http://dx.doi.org/10.21037/tcr.2020.03.30
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