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Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9

BACKGROUND: Krüppel-like factor 9 (KLF9) is one of the most important members of the KLF family, and is abnormally expressed in many tumors. However, the detailed function of KLF9 in endometrial cancer (EC) was barely investigated. METHODS: In this study, a total of 52 paired EC tissues were recruit...

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Autores principales: Yan, Xiaofang, Zhang, Huilin, Ke, Jieqi, Zhang, Yongli, Dai, Chenyun, Zhu, Mei, Jiang, Feizhou, Zhu, Hongdi, Zhang, Ling, Zuo, Xin, Li, Weiling, Yin, Xiufeng, Wan, Xiaoping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798504/
https://www.ncbi.nlm.nih.gov/pubmed/35117582
http://dx.doi.org/10.21037/tcr.2020.03.53
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author Yan, Xiaofang
Zhang, Huilin
Ke, Jieqi
Zhang, Yongli
Dai, Chenyun
Zhu, Mei
Jiang, Feizhou
Zhu, Hongdi
Zhang, Ling
Zuo, Xin
Li, Weiling
Yin, Xiufeng
Wan, Xiaoping
author_facet Yan, Xiaofang
Zhang, Huilin
Ke, Jieqi
Zhang, Yongli
Dai, Chenyun
Zhu, Mei
Jiang, Feizhou
Zhu, Hongdi
Zhang, Ling
Zuo, Xin
Li, Weiling
Yin, Xiufeng
Wan, Xiaoping
author_sort Yan, Xiaofang
collection PubMed
description BACKGROUND: Krüppel-like factor 9 (KLF9) is one of the most important members of the KLF family, and is abnormally expressed in many tumors. However, the detailed function of KLF9 in endometrial cancer (EC) was barely investigated. METHODS: In this study, a total of 52 paired EC tissues were recruited to detect the KLF9 expression. Then a serial of phenotypic experiments and mechanism researches were performed. RESULTS: The results showed that KLF9 expression was decreased in EC tissues, and the reduced expression of KLF9 is associated with highly metastatic capacity of EC cells. KLF9 could inhibit the proliferation and invasion of EC cells by inhibiting the Wnt/β-catenin signaling pathway. Progesterone receptor (PR) could bind to KLF9 promoter and a positive correlation between KLF9 and PR expression was witnessed. CONCLUSIONS: Taken together, the reduction of KLF9 induced by PR might participate in the development of EC and targeting KLF9 may provide a novel strategy for EC management.
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spelling pubmed-87985042022-02-02 Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9 Yan, Xiaofang Zhang, Huilin Ke, Jieqi Zhang, Yongli Dai, Chenyun Zhu, Mei Jiang, Feizhou Zhu, Hongdi Zhang, Ling Zuo, Xin Li, Weiling Yin, Xiufeng Wan, Xiaoping Transl Cancer Res Original Article BACKGROUND: Krüppel-like factor 9 (KLF9) is one of the most important members of the KLF family, and is abnormally expressed in many tumors. However, the detailed function of KLF9 in endometrial cancer (EC) was barely investigated. METHODS: In this study, a total of 52 paired EC tissues were recruited to detect the KLF9 expression. Then a serial of phenotypic experiments and mechanism researches were performed. RESULTS: The results showed that KLF9 expression was decreased in EC tissues, and the reduced expression of KLF9 is associated with highly metastatic capacity of EC cells. KLF9 could inhibit the proliferation and invasion of EC cells by inhibiting the Wnt/β-catenin signaling pathway. Progesterone receptor (PR) could bind to KLF9 promoter and a positive correlation between KLF9 and PR expression was witnessed. CONCLUSIONS: Taken together, the reduction of KLF9 induced by PR might participate in the development of EC and targeting KLF9 may provide a novel strategy for EC management. AME Publishing Company 2020-04 /pmc/articles/PMC8798504/ /pubmed/35117582 http://dx.doi.org/10.21037/tcr.2020.03.53 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Yan, Xiaofang
Zhang, Huilin
Ke, Jieqi
Zhang, Yongli
Dai, Chenyun
Zhu, Mei
Jiang, Feizhou
Zhu, Hongdi
Zhang, Ling
Zuo, Xin
Li, Weiling
Yin, Xiufeng
Wan, Xiaoping
Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9
title Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9
title_full Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9
title_fullStr Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9
title_full_unstemmed Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9
title_short Progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating Krüppel-like factor 9
title_sort progesterone receptor inhibits the proliferation and invasion of endometrial cancer cells by up regulating krüppel-like factor 9
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798504/
https://www.ncbi.nlm.nih.gov/pubmed/35117582
http://dx.doi.org/10.21037/tcr.2020.03.53
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