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Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review
OBJECTIVE: To describe and discuss the progression of the non-coding RNA as biomarkers in early esophageal cancer. BACKGROUND: Esophageal cancer without obvious symptoms during early stages is one of the most common cancers, the current clinical treatments offer possibilities of a cure, but the surv...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798506/ https://www.ncbi.nlm.nih.gov/pubmed/35116309 http://dx.doi.org/10.21037/tcr-21-687 |
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author | Xu, Jia Pan, Hui-Wen Wang, Xue-Qi Chen, Ke-Ping |
author_facet | Xu, Jia Pan, Hui-Wen Wang, Xue-Qi Chen, Ke-Ping |
author_sort | Xu, Jia |
collection | PubMed |
description | OBJECTIVE: To describe and discuss the progression of the non-coding RNA as biomarkers in early esophageal cancer. BACKGROUND: Esophageal cancer without obvious symptoms during early stages is one of the most common cancers, the current clinical treatments offer possibilities of a cure, but the survival rates and the prognoses remain poor, it is a serious threat to human life and health. Most patients are usually diagnosed during terminal stages due to low sensitivity of esophageal cancer’s early detection techniques. With the development of molecular biology, an increasing number of non-coding RNAs are found to be associated with the occurrence, development, and prognosis of esophageal cancer. Some of these have begun to be used in clinics and laboratories for diagnosis, treatment, and prognosis, with the goal of reducing mortality. METHODS: The information for this paper was collected from a variety of sources, including a search of the keynote’s references, a search for texts in college libraries, and discussions with experts in the field of esophageal cancer clinical treatment. CONCLUSIONS: Non-coding RNA does play a regulatory role in the development of esophageal cancer, which can predict the occurrence or prognosis of tumors, and become a new class of tumor markers and therapeutic targets in clinical applications. In this review, we survey the recent developments in the incidence, diagnosis, and treatment of esophageal cancer, especially with new research progresses on non-coding RNA biomarkers in detail, and discuss its potential clinical applications. |
format | Online Article Text |
id | pubmed-8798506 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87985062022-02-02 Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review Xu, Jia Pan, Hui-Wen Wang, Xue-Qi Chen, Ke-Ping Transl Cancer Res Review Article OBJECTIVE: To describe and discuss the progression of the non-coding RNA as biomarkers in early esophageal cancer. BACKGROUND: Esophageal cancer without obvious symptoms during early stages is one of the most common cancers, the current clinical treatments offer possibilities of a cure, but the survival rates and the prognoses remain poor, it is a serious threat to human life and health. Most patients are usually diagnosed during terminal stages due to low sensitivity of esophageal cancer’s early detection techniques. With the development of molecular biology, an increasing number of non-coding RNAs are found to be associated with the occurrence, development, and prognosis of esophageal cancer. Some of these have begun to be used in clinics and laboratories for diagnosis, treatment, and prognosis, with the goal of reducing mortality. METHODS: The information for this paper was collected from a variety of sources, including a search of the keynote’s references, a search for texts in college libraries, and discussions with experts in the field of esophageal cancer clinical treatment. CONCLUSIONS: Non-coding RNA does play a regulatory role in the development of esophageal cancer, which can predict the occurrence or prognosis of tumors, and become a new class of tumor markers and therapeutic targets in clinical applications. In this review, we survey the recent developments in the incidence, diagnosis, and treatment of esophageal cancer, especially with new research progresses on non-coding RNA biomarkers in detail, and discuss its potential clinical applications. AME Publishing Company 2021-10 /pmc/articles/PMC8798506/ /pubmed/35116309 http://dx.doi.org/10.21037/tcr-21-687 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Review Article Xu, Jia Pan, Hui-Wen Wang, Xue-Qi Chen, Ke-Ping Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review |
title | Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review |
title_full | Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review |
title_fullStr | Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review |
title_full_unstemmed | Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review |
title_short | Status of diagnosis and treatment of esophageal cancer and non-coding RNA correlation research: a narrative review |
title_sort | status of diagnosis and treatment of esophageal cancer and non-coding rna correlation research: a narrative review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798506/ https://www.ncbi.nlm.nih.gov/pubmed/35116309 http://dx.doi.org/10.21037/tcr-21-687 |
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