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Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China

BACKGROUND: To investigate the incidence of single and multiple human papillomavirus (HR-HPV) infection in CIN3 patients before operation. METHODS: The complete clinical data of patients with CIN3 by biopsy were collected. HPV23 typing in the first 3 months of the treatment was detected. The infecti...

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Autores principales: Zhao, Xuan-Yu, Kong, Wei-Min, Jiao, Si-Meng, Song, Dan, Chen, Jiao, Shang, Ruo-Tian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798541/
https://www.ncbi.nlm.nih.gov/pubmed/35117544
http://dx.doi.org/10.21037/tcr.2020.01.59
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author Zhao, Xuan-Yu
Kong, Wei-Min
Jiao, Si-Meng
Song, Dan
Chen, Jiao
Shang, Ruo-Tian
author_facet Zhao, Xuan-Yu
Kong, Wei-Min
Jiao, Si-Meng
Song, Dan
Chen, Jiao
Shang, Ruo-Tian
author_sort Zhao, Xuan-Yu
collection PubMed
description BACKGROUND: To investigate the incidence of single and multiple human papillomavirus (HR-HPV) infection in CIN3 patients before operation. METHODS: The complete clinical data of patients with CIN3 by biopsy were collected. HPV23 typing in the first 3 months of the treatment was detected. The infection rate of HPV was analyzed. RESULTS: One thousand and fifty-one HPV subtypes were detected in 679 patients with HPV (+) CIN3 with primary conization, of which the top ten were HPV16, 33, 31, 58, 6, 52, 18, 43, 51, 11, 68, respectively. Among them, single subtype HPV infection accounted for 64.36%, while multiple HPV infection accounted for 35.64%. For multiplex HPV infection, there were 2, 3, 4 species, and 148 (21.80%), 69 (10.16%), 16 (2.36%), 9 (1.33%) cases of multiple HPV infection of 5 and above HPV subtypes respectively. The incidence of multiple HPV infection in CIN3 patients in 2015 was higher than that in 2012 (39.01% vs. 30.08%, P=0.019), and the proportion of multiple infections in HPV was higher than that in the 2014 group. CONCLUSIONS: The top 10 HPV subtypes of the CIN3 patients were included in HPV nine valence vaccines except HPV43 and 51.
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spelling pubmed-87985412022-02-02 Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China Zhao, Xuan-Yu Kong, Wei-Min Jiao, Si-Meng Song, Dan Chen, Jiao Shang, Ruo-Tian Transl Cancer Res Original Article BACKGROUND: To investigate the incidence of single and multiple human papillomavirus (HR-HPV) infection in CIN3 patients before operation. METHODS: The complete clinical data of patients with CIN3 by biopsy were collected. HPV23 typing in the first 3 months of the treatment was detected. The infection rate of HPV was analyzed. RESULTS: One thousand and fifty-one HPV subtypes were detected in 679 patients with HPV (+) CIN3 with primary conization, of which the top ten were HPV16, 33, 31, 58, 6, 52, 18, 43, 51, 11, 68, respectively. Among them, single subtype HPV infection accounted for 64.36%, while multiple HPV infection accounted for 35.64%. For multiplex HPV infection, there were 2, 3, 4 species, and 148 (21.80%), 69 (10.16%), 16 (2.36%), 9 (1.33%) cases of multiple HPV infection of 5 and above HPV subtypes respectively. The incidence of multiple HPV infection in CIN3 patients in 2015 was higher than that in 2012 (39.01% vs. 30.08%, P=0.019), and the proportion of multiple infections in HPV was higher than that in the 2014 group. CONCLUSIONS: The top 10 HPV subtypes of the CIN3 patients were included in HPV nine valence vaccines except HPV43 and 51. AME Publishing Company 2020-03 /pmc/articles/PMC8798541/ /pubmed/35117544 http://dx.doi.org/10.21037/tcr.2020.01.59 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Zhao, Xuan-Yu
Kong, Wei-Min
Jiao, Si-Meng
Song, Dan
Chen, Jiao
Shang, Ruo-Tian
Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China
title Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China
title_full Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China
title_fullStr Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China
title_full_unstemmed Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China
title_short Prevalence and genotypes of human papilloma virus infection in CIN3 in Beijing, China
title_sort prevalence and genotypes of human papilloma virus infection in cin3 in beijing, china
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798541/
https://www.ncbi.nlm.nih.gov/pubmed/35117544
http://dx.doi.org/10.21037/tcr.2020.01.59
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