Cargando…

Transcriptome analysis of the effect of a novel human serine protease inhibitor SPINK13 on gene expression in MHCC97-H cells

BACKGROUND: Serine peptidase inhibitor, Kazal type 13 (SPINK13) (also known as hespinter) is a low-molecular-weight inhibitor of uPA that was discovered in 2006. It was detected in prokaryotic cells in 2013 for the first time and preliminarily shown to inhibit hepG2 liver cancer cells growth in vitr...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wei, Ling, An, Tao, An, Yunhe, He, Zheng, Jia, Tingting, Li, Baoming, Lun, Yongzhi
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798559/ https://www.ncbi.nlm.nih.gov/pubmed/35116303 http://dx.doi.org/10.21037/tcr-21-1928

Ejemplares similares

Phosphoproteomic Analysis of the Highly-Metastatic Hepatocellular Carcinoma Cell Line, MHCC97-H
por: Tian, Miaomiao, et al.
Publicado: (2015)

FK866 inhibits the epithelial-mesenchymal transition of hepatocarcinoma MHCC97-H cells
por: Zhang, Bin, et al.
Publicado: (2018)

Regulation of serine protease inhibitor Kazal type-5 (SPINK5) gene expression in the keratinocytes
por: Le, Ngoc Anh, et al.
Publicado: (2014)

Downregulation of B7-H4 in the MHCC97-H hepatocellular carcinoma cell line by arsenic trioxide
por: CUI, LIMING, et al.
Publicado: (2016)

Temporary serine protease inhibition and the role of SPINK2 in human bone marrow
por: Barresi, Vincenza, et al.
Publicado: (2023)

Myricetin inhibits migration and invasion of hepatocellular carcinoma MHCC97H cell line by inhibiting the EMT process
por: Ma, Hongxin, et al.
Publicado: (2019)

SPINK6 inhibits human airway serine proteases and restricts influenza virus activation
por: Wang, Dong, et al.
Publicado: (2021)

Triptolide Inhibits Invasion and Tumorigenesis of Hepatocellular Carcinoma MHCC-97H Cells Through NF-κB Signaling
por: Wang, Haiji, et al.
Publicado: (2016)

Casticin inhibits self-renewal of liver cancer stem cells from the MHCC97 cell line
por: HE, GUICHENG, et al.
Publicado: (2014)

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers
por: Mehner, Christine, et al.
Publicado: (2015)

MicroRNA-30a-3p acts as a tumor suppressor in MHCC-97H hepatocellular carcinoma cells by targeting COX-2
por: Yang, XueMei, et al.
Publicado: (2021)

HMGA1 participates in MHCC97H cell proliferation and invasion through the ILK/Akt/GSK3β signaling pathway
por: Liu, Li, et al.
Publicado: (2017)

MicroRNA-30a-3p acts as a tumor suppressor in MHCC-97H hepatocellular carcinoma cells by targeting COX-2: Erratum
por: Yang, XueMei, et al.
Publicado: (2022)

The Effects of a Novel Curcumin Derivative Loaded Long-Circulating Solid Lipid Nanoparticle on the MHCC-97H Liver Cancer Cells and Pharmacokinetic Behavior
por: Wei, Yumeng, et al.
Publicado: (2022)

Both Talin-1 and Talin-2 correlate with malignancy potential of the human hepatocellular carcinoma MHCC-97 L cell
por: Fang, Kun-peng, et al.
Publicado: (2016)

The Role of Serine Peptidase Inhibitor Kazal Type 13 (SPINK13) as a Clinicopathological and Prognostic Biomarker in Patients with Clear Cell Renal Cell Carcinoma
por: Xu, Wen-Hao, et al.
Publicado: (2019)

Characterization and Cytotoxicity of Polyprenol Lipid and Vitamin E-TPGS Hybrid Nanoparticles for Betulinic Acid and Low-Substituted Hydroxyl Fullerenol in MHCC97H and L02 Cells
por: Tao, Ran, et al.
Publicado: (2020)

Cordyceps cicadae induces G2/M cell cycle arrest in MHCC97H human hepatocellular carcinoma cells: a proteomic study
por: Wang, Hualin, et al.
Publicado: (2014)

Knockdown of yes-associated protein inhibits proliferation and downregulates large tumor suppressor 1 expression in MHCC97H human hepatocellular carcinoma cells
por: WANG, CHENG, et al.
Publicado: (2015)

Survivin downregulation using siRNA nanoliposomes inhibits cell proliferation and promotes the apoptosis of MHCC-97H hepatic cancer cells: An in vitro and in vivo study
por: Liu, Ziqin, et al.
Publicado: (2017)

The impact of physiological stress conditions on protein structure and trypsin inhibition of serine protease inhibitor Kazal type 1 (SPINK1) and its N34S variant
por: Buchholz, Ina, et al.
Publicado: (2020)

New human hepatocellular carcinoma (HCC) cell line with highly metastatic potential (MHCC97) and its expressions of the factors associated with metastasis
por: Tian, J, et al.
Publicado: (1999)

MicroRNA-34a-5p enhances sensitivity to chemotherapy by targeting AXL in hepatocellular carcinoma MHCC-97L cells
por: LI, XIAO-YUN, et al.
Publicado: (2015)

The effect of bone marrow mesenchymal stem cells on highly metastatic MHCC97-H hepatocellular carcinoma cells following OPN and TGFβ1 gene silencing
por: Zhang, Beibei, et al.
Publicado: (2020)

The Prevalence of Cationic Trypsinogen (PRSS1) and Serine Protease Inhibitor, Kazal Type 1 (SPINK1) Gene Mutations in Polish Patients with Alcoholic and Idiopathic Chronic Pancreatitis
por: Gasiorowska, Anita, et al.
Publicado: (2010)

Tazarotene-Induced Gene 1 (TIG1) Interacts with Serine Protease Inhibitor Kazal-Type 2 (SPINK2) to Inhibit Cellular Invasion of Testicular Carcinoma Cells
por: Shyu, Rong-Yaun, et al.
Publicado: (2019)

The role of Serine Proteases and Serine Protease Inhibitors in the migration of Gonadotropin-Releasing Hormone neurons
por: Drapkin, Paola T, et al.
Publicado: (2002)

Hydroxypyridinone-Coumarin Inhibits the Proliferation of MHCC97 and HepG2 Human Hepatocellular Carcinoma Cells and Down-Regulates the Phosphoinositide-3 Kinase Pathway
por: Cui, Xiaopeng, et al.
Publicado: (2020)

Serine Protease Inhibitor Kazal Type 1 (SPINK1) c.194+2T > C Mutation May Predict Long-term Outcome of Endoscopic Treatments in Idiopathic Chronic Pancreatitis
por: Sun, Chang, et al.
Publicado: (2015)

A protein scaffold, engineered SPINK2, for generation of inhibitors with high affinity and specificity against target proteases
por: Nishimiya, Daisuke, et al.
Publicado: (2019)

Knockdown of Urothelial Carcinoma-Associated 1 Suppressed Cell Growth and Migration Through Regulating miR-301a and CXCR4 in Osteosarcoma MHCC97 Cells
por: Zhu, Genglong, et al.
Publicado: (2018)

Role of Intrapancreatic SPINK1/Spink3 Expression in the Development of Pancreatitis
por: Ohmuraya, Masaki, et al.
Publicado: (2012)

MAPK inhibitors induce serine peptidase inhibitor Kazal type 1 (SPINK1) secretion in BRAF V600E‐mutant colorectal adenocarcinoma
por: Räsänen, Kati, et al.
Publicado: (2017)

Diarylethene‐Based Photoswitchable Inhibitors of Serine Proteases
por: Babii, Oleg, et al.
Publicado: (2021)

Editorial: Serine protease inhibitors and their therapeutic applications
por: Crocetti, Letizia, et al.
Publicado: (2022)

Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine
por: Chen, Yi-Ting, et al.
Publicado: (2022)

Serine 13 of the human cytomegalovirus viral cyclin-dependent kinase UL97 is required for regulatory protein 14-3-3 binding and UL97 stability
por: Iwahori, Satoko, et al.
Publicado: (2022)

Performance of SPINK1 and SPINK1‐based diagnostic model in detection of hepatocellular carcinoma
por: Wang, Fang, et al.
Publicado: (2021)

Hindrance of the Proteolytic Activity of Neutrophil-Derived Serine Proteases by Serine Protease Inhibitors as a Management of Cardiovascular Diseases and Chronic Inflammation
por: Burster, Timo, et al.
Publicado: (2021)

Docetaxel-loaded lipid microbubbles combined with ultrasound-triggered microbubble destruction for targeted tumor therapy in MHCC-H cells
por: Zhang, Yue, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_1gq3m014ucsc41r78gr8d4tmat