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Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population
INTRODUCTION: Microvasculopathy is characterized by progressive structural and functional damage to the microvessels and plays a key role in the pathogenesis of various connective tissue diseases (CTD). Nailfold videocapillaroscopy is an optimal and validated method for analysis of microvascular abn...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Rambam Health Care Campus
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798589/ https://www.ncbi.nlm.nih.gov/pubmed/35089122 http://dx.doi.org/10.5041/RMMJ.10460 |
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author | Sundaray, Sambit Mishra, Siddhartha Dash, Subhash Chandra Sundaray, Naba Kishore |
author_facet | Sundaray, Sambit Mishra, Siddhartha Dash, Subhash Chandra Sundaray, Naba Kishore |
author_sort | Sundaray, Sambit |
collection | PubMed |
description | INTRODUCTION: Microvasculopathy is characterized by progressive structural and functional damage to the microvessels and plays a key role in the pathogenesis of various connective tissue diseases (CTD). Nailfold videocapillaroscopy is an optimal and validated method for analysis of microvascular abnormalities and is able to differentiate secondary Raynaud’s phenomenon (RP) of CTD from primary RP and healthy subjects. AIM: To assess and analyze nailfold capillaroscopic findings in Indian subjects with secondary Raynaud and to compare with findings in healthy subjects. METHODS: A total of 62 study participants including cases and controls underwent nailfold videocapillaroscopy. Capillary loop length, capillary width, capillary density, presence/absence of tortuosity, giant loops, neoangiogenesis, microhemorrhages, and avascular areas were the parameters studied. RESULTS: All the quantitative and qualitative parameters studied were significantly associated with secondary RP. Mean loop length in cases of connective tissue diseases was significantly less than in the controls (225.74 μm versus 282.97 μm) (P=0.002). Capillary density was also reduced significantly in the cases as compared to the controls (4.6 versus 7.39/mm) (P<0.01), whereas it was markedly decreased in systemic sclerosis (SSc) and mixed connective tissue diseases (MCTD), and near normal in systemic lupus erythematosus (SLE). Tortuosity was the most frequent (77.4%) qualitative parameter. Scleroderma pattern was found in 62.5% of patients with SSc and in 60% with MCTD. Non-specific pattern was found in 80% of SLE cases and 50% of dermatomyositis cases. CONCLUSION: Both quantitative and qualitative capillaroscopic changes are significantly associated with secondary RP. Scleroderma pattern was predominant in SSc and MCTD, whereas non-specific pattern was predominantly found in SLE and dermatomyositis. |
format | Online Article Text |
id | pubmed-8798589 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Rambam Health Care Campus |
record_format | MEDLINE/PubMed |
spelling | pubmed-87985892022-01-29 Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population Sundaray, Sambit Mishra, Siddhartha Dash, Subhash Chandra Sundaray, Naba Kishore Rambam Maimonides Med J Original Research INTRODUCTION: Microvasculopathy is characterized by progressive structural and functional damage to the microvessels and plays a key role in the pathogenesis of various connective tissue diseases (CTD). Nailfold videocapillaroscopy is an optimal and validated method for analysis of microvascular abnormalities and is able to differentiate secondary Raynaud’s phenomenon (RP) of CTD from primary RP and healthy subjects. AIM: To assess and analyze nailfold capillaroscopic findings in Indian subjects with secondary Raynaud and to compare with findings in healthy subjects. METHODS: A total of 62 study participants including cases and controls underwent nailfold videocapillaroscopy. Capillary loop length, capillary width, capillary density, presence/absence of tortuosity, giant loops, neoangiogenesis, microhemorrhages, and avascular areas were the parameters studied. RESULTS: All the quantitative and qualitative parameters studied were significantly associated with secondary RP. Mean loop length in cases of connective tissue diseases was significantly less than in the controls (225.74 μm versus 282.97 μm) (P=0.002). Capillary density was also reduced significantly in the cases as compared to the controls (4.6 versus 7.39/mm) (P<0.01), whereas it was markedly decreased in systemic sclerosis (SSc) and mixed connective tissue diseases (MCTD), and near normal in systemic lupus erythematosus (SLE). Tortuosity was the most frequent (77.4%) qualitative parameter. Scleroderma pattern was found in 62.5% of patients with SSc and in 60% with MCTD. Non-specific pattern was found in 80% of SLE cases and 50% of dermatomyositis cases. CONCLUSION: Both quantitative and qualitative capillaroscopic changes are significantly associated with secondary RP. Scleroderma pattern was predominant in SSc and MCTD, whereas non-specific pattern was predominantly found in SLE and dermatomyositis. Rambam Health Care Campus 2022-01-27 /pmc/articles/PMC8798589/ /pubmed/35089122 http://dx.doi.org/10.5041/RMMJ.10460 Text en © 2022 Sundaray et al. https://creativecommons.org/licenses/by/3.0/This is an open-access article. All its content, except where otherwise noted, is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0 (https://creativecommons.org/licenses/by/3.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Research Sundaray, Sambit Mishra, Siddhartha Dash, Subhash Chandra Sundaray, Naba Kishore Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population |
title | Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population |
title_full | Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population |
title_fullStr | Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population |
title_full_unstemmed | Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population |
title_short | Nailfold Videocapillaroscopy in Connective Tissue Diseases with Raynaud’s Phenomenon in an Indian Population |
title_sort | nailfold videocapillaroscopy in connective tissue diseases with raynaud’s phenomenon in an indian population |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798589/ https://www.ncbi.nlm.nih.gov/pubmed/35089122 http://dx.doi.org/10.5041/RMMJ.10460 |
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