Role of Anopheles Mosquitoes in Cache Valley Virus Lineage Displacement, New York, USA

Cache Valley virus (CVV) is a mosquitoborne virus that infects livestock and humans. We report results of surveillance for CVV in New York, USA, during 2000–2016; full-genome analysis of selected CVV isolates from sheep, horse, humans, and mosquitoes from New York and Canada; and phenotypic characte...

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Detalles Bibliográficos
Autores principales: Dieme, Constentin, Ngo, Kiet A., Tyler, Shaun, Maffei, Joseph G., Zink, Steven D., Dupuis, Alan P., Koetzner, Cheri A., Shultis, Chelsea, Stout, Jessica, Payne, Anne F., Backenson, P. Bryon, Kuo, Lili, Drebot, Michael A., Ciota, Alexander T., Kramer, Laura D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Centers for Disease Control and Prevention 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798675/
https://www.ncbi.nlm.nih.gov/pubmed/35075998
http://dx.doi.org/10.3201/eid2802.203810
Descripción
Sumario:Cache Valley virus (CVV) is a mosquitoborne virus that infects livestock and humans. We report results of surveillance for CVV in New York, USA, during 2000–2016; full-genome analysis of selected CVV isolates from sheep, horse, humans, and mosquitoes from New York and Canada; and phenotypic characterization of selected strains. We calculated infection rates by using the maximum-likelihood estimation method by year, region, month, and mosquito species. The highest maximum-likelihood estimations were for Anopheles spp. mosquitoes. Our phylogenetic analysis identified 2 lineages and found evidence of segment reassortment. Furthermore, our data suggest displacement of CVV lineage 1 by lineage 2 in New York and Canada. Finally, we showed increased vector competence of An. quadrimaculatus mosquitoes for lineage 2 strains of CVV compared with lineage 1 strains.

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