Cargando…

Polyphyllin I suppresses proliferation and promotes apoptosis of gastric cancer cell by inhibiting stat3 phosphorylation

BACKGROUND: Polyphyllin I, a bioactive phytochemical extracted from Rhizoma Paridis, has been reported to exhibit anticancer activity. However, little is known about the potential of Polyphyllin I in induction of gastric cancer (GC) cell apoptosis and its underlying mechanisms. METHODS: Dual-lucifer...

Descripción completa

Detalles Bibliográficos
Autores principales:	Han, Jun, Kan, Jie, Wang, Xinguo, Yuan, Qingling, Song, Xiaoyan, Huang, Min, Wu, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2020
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798830/ https://www.ncbi.nlm.nih.gov/pubmed/35117835 http://dx.doi.org/10.21037/tcr-20-66

Ejemplares similares

Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
por: Zheng, Fang, et al.
Publicado: (2023)

Corrigendum: Polyphyllin I suppresses the gastric cancer growth by promoting cancer cell ferroptosis
por: Zheng, Fang, et al.
Publicado: (2023)

Synergistic Anticancer Effects of Polyphyllin I and Evodiamine on Freshly-Removed Human Gastric Tumors
por: Yue, Guofeng, et al.
Publicado: (2013)

Polyphyllin I Inhibits Propionibacterium acnes-Induced Inflammation In Vitro
por: Zhu, Tingting, et al.
Publicado: (2018)

Chloroquine suppresses proliferation and invasion and induces apoptosis of osteosarcoma cells associated with inhibition of phosphorylation of STAT3
por: Chen, Chenglong, et al.
Publicado: (2021)

Polyphyllin VII suppresses cell proliferation, the cell cycle and cell migration in colorectal cancer
por: Song, Cheng, et al.
Publicado: (2021)

Polyphyllin I inhibits the growth of ovarian cancer cells in nude mice
por: Gu, Linhui, et al.
Publicado: (2016)

Polyphyllin I Effects Candida albicans via Inhibition of Virulence Factors
por: Sun, Ai-Mei, et al.
Publicado: (2023)

Polyphyllin B Suppresses Gastric Tumor Growth by Modulating Iron Metabolism and Inducing Ferroptosis
por: Hu, Can, et al.
Publicado: (2023)

Polyphyllin I Promotes Autophagic Cell Death and Apoptosis of Colon Cancer Cells via the ROS-Inhibited AKT/mTOR Pathway
por: Luo, Qihui, et al.
Publicado: (2022)

Polyphyllin I suppresses the formation of vasculogenic mimicry via Twist1/VE-cadherin pathway
por: Xiao, Ting, et al.
Publicado: (2018)

Promotion of Ros-mediated Bax/Cyt-c apoptosis by polyphyllin II leads to suppress growth and aggression of glioma cells
por: Cheng, Guang, et al.
Publicado: (2021)

Polyphyllin II induced apoptosis of NSCLC cells by inhibiting autophagy through the mTOR pathway
por: Jiao, Yuhan, et al.
Publicado: (2022)

Inhibition of STAT3(Y705) phosphorylation by Stattic suppresses proliferation and induces mitochondrial-dependent apoptosis in pancreatic cancer cells
por: Guo, Hangcheng, et al.
Publicado: (2022)

Polyphyllin I suppresses human osteosarcoma growth by inactivation of Wnt/β-catenin pathway in vitro and in vivo
por: Chang, Junli, et al.
Publicado: (2017)

Polyphyllin II Induces Protective Autophagy and Apoptosis via Inhibiting PI3K/AKT/mTOR and STAT3 Signaling in Colorectal Cancer Cells
por: Li, Jun-Kui, et al.
Publicado: (2022)

Polyphyllin I Promoted Melanoma Cells Autophagy and Apoptosis via PI3K/Akt/mTOR Signaling Pathway
por: Long, Jianwen, et al.
Publicado: (2020)

The protective effect of polyphyllin I on myocardial ischemia/reperfusion injury in rats
por: Huang, Ruizhen, et al.
Publicado: (2020)

Polyphyllin VII Promotes Apoptosis and Autophagic Cell Death via ROS-Inhibited AKT Activity, and Sensitizes Glioma Cells to Temozolomide
por: Pang, Dejiang, et al.
Publicado: (2019)

Natural Polyphyllins (I, II, D, VI, VII) Reverses Cancer Through Apoptosis, Autophagy, Mitophagy, Inflammation, and Necroptosis
por: Ahmad, Bashir, et al.
Publicado: (2021)

Polyphyllin I Ameliorates Collagen-Induced Arthritis by Suppressing the Inflammation Response in Macrophages Through the NF-κB Pathway
por: Wang, Qiong, et al.
Publicado: (2018)

The synergistic anticancer effect of formosanin C and polyphyllin VII based on caspase‐mediated cleavage of Beclin1 inhibiting autophagy and promoting apoptosis
por: Cui, Jingxia, et al.
Publicado: (2018)

Polyphyllin I suppressed the apoptosis of intervertebral disc nucleus pulposus cells induced by IL-1β by miR-503-5p/Bcl-2 axis
por: Yuan, Lei, et al.
Publicado: (2023)

LncRNA SNHG16 Functions as an Oncogene by Sponging MiR-135a and Promotes JAK2/STAT3 Signal Pathway in Gastric Cancer
por: Wang, Xinguo, et al.
Publicado: (2019)

MiR-124-3p mediates gastric cancer cell ferroptosis induced by an anti-cancer drug polyphyllin I
por: Zheng, Fang, et al.
Publicado: (2023)

Schizandrin A induces the apoptosis and suppresses the proliferation, invasion and migration of gastric cancer cells by activating endoplasmic reticulum stress
por: Pu, Huachao, et al.
Publicado: (2021)

Polyphyllin VI induces apoptosis and autophagy in human osteosarcoma cells by modulation of ROS/JNK activation
por: Yuan, Yong-Liang, et al.
Publicado: (2019)

hSulf-1 inhibits cell proliferation and migration and promotes apoptosis by suppressing stat3 signaling in hepatocellular carcinoma
por: LIU, LING, et al.
Publicado: (2014)

Carfilzomib inhibits the proliferation and apoptosis of multiple myeloma cells by inhibiting STAT1/COX-2/iNOS signaling pathway
por: He, Shaolong, et al.
Publicado: (2022)

Cryptotanshinone inhibits proliferation yet induces apoptosis by suppressing STAT3 signals in renal cell carcinoma
por: Chen, Zhiguo, et al.
Publicado: (2017)

A new agent developed by biotransformation of polyphyllin VII inhibits chemoresistance in breast cancer
por: He, Dong-Xu, et al.
Publicado: (2015)

Polyphyllin I and VII potentiate the chemosensitivity of A549/DDP cells to cisplatin by enhancing apoptosis, reversing EMT and suppressing the CIP2A/AKT/mTOR signaling axis
por: Feng, Feifei, et al.
Publicado: (2019)

A novel synthetic Asiatic acid derivative induces apoptosis and inhibits proliferation and mobility of gastric cancer cells by suppressing STAT3 signaling pathway
por: Wang, Gang, et al.
Publicado: (2016)

Bufotalin Suppresses Proliferation and Metastasis of Triple-Negative Breast Cancer Cells by Promoting Apoptosis and Inhibiting the STAT3/EMT Axis
por: Park, So Jin, et al.
Publicado: (2023)

Polyphyllin II inhibits liver cancer cell proliferation, migration and invasion through downregulated cofilin activity and the AKT/NF-κB pathway
por: Pang, Dejiang, et al.
Publicado: (2020)

Combined inhibition of STAT and Notch signalling effectively suppresses tumourigenesis by inducing apoptosis and inhibiting proliferation, migration and invasion in glioblastoma cells
por: Tulip, Israt Jahan, et al.
Publicado: (2021)

Inhibition of GLS suppresses proliferation and promotes apoptosis in prostate cancer
por: Zhang, Junfeng, et al.
Publicado: (2019)

Interaction Of c-Jun And HOTAIR- Increased Expression Of p21 Converge In Polyphyllin I-Inhibited Growth Of Human Lung Cancer Cells
por: Zhao, YueYang, et al.
Publicado: (2019)

Momordicine I suppresses glioma growth by promoting apoptosis and impairing mitochondrial oxidative phosphorylation
por: Kao, Ying, et al.
Publicado: (2023)

Role of the Death Receptor and Endoplasmic Reticulum Stress Signaling Pathways in Polyphyllin I-Regulated Apoptosis of Human Hepatocellular Carcinoma HepG2 Cells
por: Luo, Qihui, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_c6ra1rklfurt02v6qvgeofv28e