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Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review
Radiation therapy and systemic therapy are the primary non-surgical treatment modalities for head and neck squamous cell carcinoma (HNSCC). Despite advances in our biologic understanding of this disease and the development of novel therapeutics, treatment resistance remains a significant problem. It...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798834/ https://www.ncbi.nlm.nih.gov/pubmed/35116571 http://dx.doi.org/10.21037/tcr-20-2096 |
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author | Hayman, Thomas J. Bhatia, Aarti K. Jethwa, Krishan R. Young, Melissa R. Park, Henry S. |
author_facet | Hayman, Thomas J. Bhatia, Aarti K. Jethwa, Krishan R. Young, Melissa R. Park, Henry S. |
author_sort | Hayman, Thomas J. |
collection | PubMed |
description | Radiation therapy and systemic therapy are the primary non-surgical treatment modalities for head and neck squamous cell carcinoma (HNSCC). Despite advances in our biologic understanding of this disease and the development of novel therapeutics, treatment resistance remains a significant problem. It has become increasingly evident that the innate and adaptive immune systems play a significant role in the modulation of anti-tumor responses to traditional cancer-directed therapies. By inducing DNA damage and cell death, radiation therapy appears to activate both innate and adaptive immune responses. Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) also have yielded promising results, particularly in the recurrent/metastatic setting. In this review, we will discuss the rationale for combining radiotherapy with immunotherapy to harness the immunomodulatory effects of radiation therapy on HNSCC, as well as biomarkers for immune response. We will also review recent preclinical and clinical data exploring these combinations in various contexts, including recurrent/metastatic and locally advanced disease. Among those with locally advanced HNSCC, we will discuss clinical trials employing immunotherapy either concurrently with radiation therapy or as maintenance following chemoradiation in both the definitive and postoperative settings, with or without the use of cisplatin-based or non-cisplatin-based chemotherapy. |
format | Online Article Text |
id | pubmed-8798834 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87988342022-02-02 Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review Hayman, Thomas J. Bhatia, Aarti K. Jethwa, Krishan R. Young, Melissa R. Park, Henry S. Transl Cancer Res Review Article on Synergy in Action: Novel Approaches to Combining Radiation Therapy and Immunotherapy Radiation therapy and systemic therapy are the primary non-surgical treatment modalities for head and neck squamous cell carcinoma (HNSCC). Despite advances in our biologic understanding of this disease and the development of novel therapeutics, treatment resistance remains a significant problem. It has become increasingly evident that the innate and adaptive immune systems play a significant role in the modulation of anti-tumor responses to traditional cancer-directed therapies. By inducing DNA damage and cell death, radiation therapy appears to activate both innate and adaptive immune responses. Immunotherapies targeting programmed cell death protein 1 (PD-1) and programmed cell death ligand 1 (PD-L1) also have yielded promising results, particularly in the recurrent/metastatic setting. In this review, we will discuss the rationale for combining radiotherapy with immunotherapy to harness the immunomodulatory effects of radiation therapy on HNSCC, as well as biomarkers for immune response. We will also review recent preclinical and clinical data exploring these combinations in various contexts, including recurrent/metastatic and locally advanced disease. Among those with locally advanced HNSCC, we will discuss clinical trials employing immunotherapy either concurrently with radiation therapy or as maintenance following chemoradiation in both the definitive and postoperative settings, with or without the use of cisplatin-based or non-cisplatin-based chemotherapy. AME Publishing Company 2021-05 /pmc/articles/PMC8798834/ /pubmed/35116571 http://dx.doi.org/10.21037/tcr-20-2096 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Review Article on Synergy in Action: Novel Approaches to Combining Radiation Therapy and Immunotherapy Hayman, Thomas J. Bhatia, Aarti K. Jethwa, Krishan R. Young, Melissa R. Park, Henry S. Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review |
title | Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review |
title_full | Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review |
title_fullStr | Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review |
title_full_unstemmed | Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review |
title_short | Combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review |
title_sort | combinations of immunotherapy and radiation therapy in head and neck squamous cell carcinoma: a narrative review |
topic | Review Article on Synergy in Action: Novel Approaches to Combining Radiation Therapy and Immunotherapy |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798834/ https://www.ncbi.nlm.nih.gov/pubmed/35116571 http://dx.doi.org/10.21037/tcr-20-2096 |
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