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Withaferin A suppresses skin tumor promotion by inhibiting proteasome-dependent isocitrate dehydrogenase 1 degradation

BACKGROUND: The metabolic enzyme isocitrate dehydrogenase 1 (IDH1) belonging to β-decarboxylase dehydrogenase family has been identified as a tumor suppressor. Withaferin A (WA), a bioactive compound derived from Withania somnifera, has the anti-tumor activity. Based on the data set that WA inhibite...

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Detalles Bibliográficos
Autores principales:	Xu, Kaiyue, Zhang, Chunjing, Li, Youbo, Xi, Xin, Zheng, Lishuang, Meng, Ming, Liu, Tongtong, Zhao, Yunfeng, Li, Wenjuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	AME Publishing Company 2019
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798856/ https://www.ncbi.nlm.nih.gov/pubmed/35116997 http://dx.doi.org/10.21037/tcr.2019.09.57

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