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Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma
Esophageal epithelial malignancy can be divided into esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). EAC is currently the seventh leading cause of death in US. Although ESCC occurs frequently in China and the population of EAC is mostly distributed in the western countries, with...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798933/ https://www.ncbi.nlm.nih.gov/pubmed/35117190 http://dx.doi.org/10.21037/tcr.2019.11.12 |
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author | Chen, Mei Ye, Xiaojun Wang, Ruihua Poon, Karen |
author_facet | Chen, Mei Ye, Xiaojun Wang, Ruihua Poon, Karen |
author_sort | Chen, Mei |
collection | PubMed |
description | Esophageal epithelial malignancy can be divided into esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). EAC is currently the seventh leading cause of death in US. Although ESCC occurs frequently in China and the population of EAC is mostly distributed in the western countries, with the change of lifestyle, diabetes, smoking, gastroesophageal exhalation disease, Barrett’s esophagus (BE) and obesity have been confirmed as high-risk factors of EAC. The number of those high-risk groups in China is increasing, and the incidence of EAC in China is likely to increase in the future. At present, there is no clear epidemiological data of EAC in China. Attention should be paid to the pathogenesis, treatment plan and prognosis of EAC. In 2018, updated epidemiological data from the national institutes of health showed that the mortality rate of EAC patients diagnosed between 1975 and 2015 was as high as 91.6%. Currently, it is believed that the causes of poor prognosis, low survival rate, recurrence, metastasis, chemotherapy resistance and radiation resistance of malignant tumors may be closely related to the existence of cancer stem cells (CSCs). This paper reviews the source of BE, the CSC markers of EAC, the correlation among bile acid, IL-6/STAT3 signaling pathway and EAC, as well as the possible source of CSCs. |
format | Online Article Text |
id | pubmed-8798933 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87989332022-02-02 Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma Chen, Mei Ye, Xiaojun Wang, Ruihua Poon, Karen Transl Cancer Res Review Article Esophageal epithelial malignancy can be divided into esophageal squamous cell carcinoma (ESCC) and adenocarcinoma (EAC). EAC is currently the seventh leading cause of death in US. Although ESCC occurs frequently in China and the population of EAC is mostly distributed in the western countries, with the change of lifestyle, diabetes, smoking, gastroesophageal exhalation disease, Barrett’s esophagus (BE) and obesity have been confirmed as high-risk factors of EAC. The number of those high-risk groups in China is increasing, and the incidence of EAC in China is likely to increase in the future. At present, there is no clear epidemiological data of EAC in China. Attention should be paid to the pathogenesis, treatment plan and prognosis of EAC. In 2018, updated epidemiological data from the national institutes of health showed that the mortality rate of EAC patients diagnosed between 1975 and 2015 was as high as 91.6%. Currently, it is believed that the causes of poor prognosis, low survival rate, recurrence, metastasis, chemotherapy resistance and radiation resistance of malignant tumors may be closely related to the existence of cancer stem cells (CSCs). This paper reviews the source of BE, the CSC markers of EAC, the correlation among bile acid, IL-6/STAT3 signaling pathway and EAC, as well as the possible source of CSCs. AME Publishing Company 2020-01 /pmc/articles/PMC8798933/ /pubmed/35117190 http://dx.doi.org/10.21037/tcr.2019.11.12 Text en 2020 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Review Article Chen, Mei Ye, Xiaojun Wang, Ruihua Poon, Karen Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma |
title | Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma |
title_full | Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma |
title_fullStr | Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma |
title_full_unstemmed | Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma |
title_short | Research progress of cancer stem cells and IL-6/STAT3 signaling pathway in esophageal adenocarcinoma |
title_sort | research progress of cancer stem cells and il-6/stat3 signaling pathway in esophageal adenocarcinoma |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798933/ https://www.ncbi.nlm.nih.gov/pubmed/35117190 http://dx.doi.org/10.21037/tcr.2019.11.12 |
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