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The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression
BACKGROUND: The abnormal expression of deoxyribonucleic acid (DNA) repair genes might be the cause of tumor development and resistance of malignant cells to chemotherapeutic drugs. A risk model based on the X-ray repair of cross-complementary (XRCC) genes was constructed to improve the diagnosis and...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
AME Publishing Company
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798971/ https://www.ncbi.nlm.nih.gov/pubmed/35116299 http://dx.doi.org/10.21037/tcr-21-1431 |
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author | Zhang, Qun-Xian Yang, Ye Yang, Heng Guo, Qiang Guo, Jia-Long Liu, Hua-Song Zhang, Jun Li, Dan |
author_facet | Zhang, Qun-Xian Yang, Ye Yang, Heng Guo, Qiang Guo, Jia-Long Liu, Hua-Song Zhang, Jun Li, Dan |
author_sort | Zhang, Qun-Xian |
collection | PubMed |
description | BACKGROUND: The abnormal expression of deoxyribonucleic acid (DNA) repair genes might be the cause of tumor development and resistance of malignant cells to chemotherapeutic drugs. A risk model based on the X-ray repair of cross-complementary (XRCC) genes was constructed to improve the diagnosis and treatment of lung adenocarcinoma (LUAD) patients. METHODS: The expression levels, diagnostic values, and prognostic values of XRCC genes were identified, and the roles and regulatory mechanisms of the risk model based on the XRCC4/5/6 in LUAD progression was explored via The Cancer Genome Atlas (TCGA) and Oncomine databases. RESULTS: XRCC1/2/3/4/5/6, XRCC7 (PRKDC), and XRCC9 (FANCG) were overexpressed, and had diagnostic value for LUAD. The XRCC genes were involved in DNA repair, and participated in the regulation of non-homologous end-joining, homologous recombination, etc. The overall survival (OS), tumor (T) stage, and survival status of patients were significantly different between the Cluster1 and Cluster2 groups. XRCC4/5/6 were independent risk factors affecting the prognosis of LUAD patients. The risk score was related to the prognosis, sex, clinical stage, T, lymph node (N), and metastasis (M) stage, as well as the survival status of LUAD patients. The clinical stage and risk score were independent risk factors for poor prognosis in LUAD patients. The risk model was involved in RNA degradation, cell cycle, basal transcription factors, DNA replication etc. The risk scores were significantly correlated with the expression levels of TGFBR1, CD160, TNFSF4, TNFRSF14, IL6R, CXCL16, TNFRSF25, TAPBP, CCL16, and CCL14. CONCLUSIONS: The risk model based on the XRCC4/5/6 genes could predict the progression of LUAD patients. |
format | Online Article Text |
id | pubmed-8798971 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | AME Publishing Company |
record_format | MEDLINE/PubMed |
spelling | pubmed-87989712022-02-02 The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression Zhang, Qun-Xian Yang, Ye Yang, Heng Guo, Qiang Guo, Jia-Long Liu, Hua-Song Zhang, Jun Li, Dan Transl Cancer Res Original Article BACKGROUND: The abnormal expression of deoxyribonucleic acid (DNA) repair genes might be the cause of tumor development and resistance of malignant cells to chemotherapeutic drugs. A risk model based on the X-ray repair of cross-complementary (XRCC) genes was constructed to improve the diagnosis and treatment of lung adenocarcinoma (LUAD) patients. METHODS: The expression levels, diagnostic values, and prognostic values of XRCC genes were identified, and the roles and regulatory mechanisms of the risk model based on the XRCC4/5/6 in LUAD progression was explored via The Cancer Genome Atlas (TCGA) and Oncomine databases. RESULTS: XRCC1/2/3/4/5/6, XRCC7 (PRKDC), and XRCC9 (FANCG) were overexpressed, and had diagnostic value for LUAD. The XRCC genes were involved in DNA repair, and participated in the regulation of non-homologous end-joining, homologous recombination, etc. The overall survival (OS), tumor (T) stage, and survival status of patients were significantly different between the Cluster1 and Cluster2 groups. XRCC4/5/6 were independent risk factors affecting the prognosis of LUAD patients. The risk score was related to the prognosis, sex, clinical stage, T, lymph node (N), and metastasis (M) stage, as well as the survival status of LUAD patients. The clinical stage and risk score were independent risk factors for poor prognosis in LUAD patients. The risk model was involved in RNA degradation, cell cycle, basal transcription factors, DNA replication etc. The risk scores were significantly correlated with the expression levels of TGFBR1, CD160, TNFSF4, TNFRSF14, IL6R, CXCL16, TNFRSF25, TAPBP, CCL16, and CCL14. CONCLUSIONS: The risk model based on the XRCC4/5/6 genes could predict the progression of LUAD patients. AME Publishing Company 2021-10 /pmc/articles/PMC8798971/ /pubmed/35116299 http://dx.doi.org/10.21037/tcr-21-1431 Text en 2021 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/. |
spellingShingle | Original Article Zhang, Qun-Xian Yang, Ye Yang, Heng Guo, Qiang Guo, Jia-Long Liu, Hua-Song Zhang, Jun Li, Dan The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression |
title | The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression |
title_full | The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression |
title_fullStr | The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression |
title_full_unstemmed | The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression |
title_short | The roles of risk model based on the 3-XRCC genes in lung adenocarcinoma progression |
title_sort | roles of risk model based on the 3-xrcc genes in lung adenocarcinoma progression |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798971/ https://www.ncbi.nlm.nih.gov/pubmed/35116299 http://dx.doi.org/10.21037/tcr-21-1431 |
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