Treatment method and prognostic factors of chondrosarcoma: based on Surveillance, Epidemiology, and End Results (SEER) database

BACKGROUND: Chondrosarcoma is a malignant tumor originating from cartilage tissue. It is the second most malignant bone tumor, accounting for about 10% to 15% of all primary bone tumors. So far, there have been no reports of large-scale clinical statistics on the relationship between non-surgical treatment and prognosis in patients with chondrosarcoma. METHODS: Through the search of the Surveillance, Epidemiology, and End Results (SEER) database, chondrosarcoma patients registered between January 1, 2004 and December 31, 2016 were selected as research goals. Univariate analysis of overall survival (OS) and chondrosarcoma-specific survival (CSSS) by Kaplan-Meier survival analysis and log-rank test. Mapping Kaplan-Meier curves for prognostic factors that are significant for OS and CSSS in patients with chondrosarcoma. After univariate analysis, the prognostic factors that have a significant effect on the prognosis were included in the multivariate Cox regression analysis, and the independent factors that affected the prognosis were screened. RESULTS: A total of 1,128 patients with chondrosarcoma were included in the study. Univariate analysis showed that prognostic factors such as age, gender, primary site, histological type, grade, tumor size, metastasis, surgery, radiotherapy, chemotherapy and treatment method had significant effects on all-cause mortality (ACM) and chondrosarcoma-specific mortality (CSSM). These factors were included in the multivariate Cox regression analysis. The results showed age, primary site, histological type, grade, tumor size, metastasis, and treatment method were independent factors affecting ACM and CSSM. CONCLUSIONS: This study found that although non-surgical treatment of chondrosarcoma has made great progress, at present, it is still not considered that non-surgical treatment can significantly improve the prognosis. There are many factors affecting the prognosis of chondrosarcoma, including age, primary site, histological type, grade, tumor size, distant metastasis and treatment method. In the future, more samples and more detailed data will be needed to study the treatment of chondrosarcoma and to analyze the important factors affecting prognosis through big data analysis.