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Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma

BACKGROUND: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsi...

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Autores principales: Park, Jong Y., Luu, Hung N., Park, Hyun Y., Lin, Hui-Yi, Radlein, Selina, Di Pietro, Giuliano, Yeo, Chang Dong, Kim, Seung Joon, Kang, Nahyeon, Antwi, Samuel, Sexton, Wade J., Spiess, Philippe E., Dickinson, Shohreh, Parker, Alexander
Formato: Online Artículo Texto
Lenguaje:English
Publicado: AME Publishing Company 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798989/
https://www.ncbi.nlm.nih.gov/pubmed/35117117
http://dx.doi.org/10.21037/tcr.2019.06.36
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author Park, Jong Y.
Luu, Hung N.
Park, Hyun Y.
Lin, Hui-Yi
Radlein, Selina
Di Pietro, Giuliano
Yeo, Chang Dong
Kim, Seung Joon
Kang, Nahyeon
Antwi, Samuel
Sexton, Wade J.
Spiess, Philippe E.
Dickinson, Shohreh
Parker, Alexander
author_facet Park, Jong Y.
Luu, Hung N.
Park, Hyun Y.
Lin, Hui-Yi
Radlein, Selina
Di Pietro, Giuliano
Yeo, Chang Dong
Kim, Seung Joon
Kang, Nahyeon
Antwi, Samuel
Sexton, Wade J.
Spiess, Philippe E.
Dickinson, Shohreh
Parker, Alexander
author_sort Park, Jong Y.
collection PubMed
description BACKGROUND: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. METHODS: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case–control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. RESULTS: As expected, increasing age was inversely correlated with RTL (Pearson r=−0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P<0.001]. In contrast, average RTL was not significantly different by gender, race, smoking status among controls or by clinical stages among RCC cases. In regression analysis, we observed that shorter RTL is significantly associated with RCC risk [odds ratio (OR) =1.48; 95% confidence interval (CI): 1.27–1.71] after adjustment for covariates. CONCLUSIONS: We found that shorter RTL is associated with an increased risk for RCC. Our findings suggest that telomere length may be involved in the development of RCC.
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spelling pubmed-87989892022-02-02 Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma Park, Jong Y. Luu, Hung N. Park, Hyun Y. Lin, Hui-Yi Radlein, Selina Di Pietro, Giuliano Yeo, Chang Dong Kim, Seung Joon Kang, Nahyeon Antwi, Samuel Sexton, Wade J. Spiess, Philippe E. Dickinson, Shohreh Parker, Alexander Transl Cancer Res Original Article BACKGROUND: Telomeres are essential for chromosomal stability and may play a key role in carcinogenesis. Telomere length is suggested as a tentative biomarker of risk for renal cell carcinoma (RCC). However, results of previous association studies between telomere length and risk for RCC are inconsistent. METHODS: We evaluated RCC risk in relation to peripheral blood leukocyte telomere length using a hospital-based case–control study of 169 RCC cases and 189 controls. Cases were histologically-confirmed RCC patients who were treated at the Moffitt Cancer Center (Tampa, FL). Controls with no history of cancer underwent a screening exam at the Lifetime Cancer Screening Center at Moffitt Cancer Center to rule out the presence of cancer. Relative telomere length (RTL) was measured by quantitative real-time polymerase chain reaction (PCR) using peripheral blood leukocyte DNA. Logistic regression was used to determine the association between RTL and RCC risk. RESULTS: As expected, increasing age was inversely correlated with RTL (Pearson r=−0.213, P=0.003) among controls but not cases. Average RTL was significantly shorter in cases as compared with controls [mean ± standard deviation (SD): 3.18±1.50 and 4.39±1.99, respectively, P<0.001]. In contrast, average RTL was not significantly different by gender, race, smoking status among controls or by clinical stages among RCC cases. In regression analysis, we observed that shorter RTL is significantly associated with RCC risk [odds ratio (OR) =1.48; 95% confidence interval (CI): 1.27–1.71] after adjustment for covariates. CONCLUSIONS: We found that shorter RTL is associated with an increased risk for RCC. Our findings suggest that telomere length may be involved in the development of RCC. AME Publishing Company 2019-07 /pmc/articles/PMC8798989/ /pubmed/35117117 http://dx.doi.org/10.21037/tcr.2019.06.36 Text en 2019 Translational Cancer Research. All rights reserved. https://creativecommons.org/licenses/by-nc-nd/4.0/Open Access Statement: This is an Open Access article distributed in accordance with the Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License (CC BY-NC-ND 4.0), which permits the non-commercial replication and distribution of the article with the strict proviso that no changes or edits are made and the original work is properly cited (including links to both the formal publication through the relevant DOI and the license). See: https://creativecommons.org/licenses/by-nc-nd/4.0/.
spellingShingle Original Article
Park, Jong Y.
Luu, Hung N.
Park, Hyun Y.
Lin, Hui-Yi
Radlein, Selina
Di Pietro, Giuliano
Yeo, Chang Dong
Kim, Seung Joon
Kang, Nahyeon
Antwi, Samuel
Sexton, Wade J.
Spiess, Philippe E.
Dickinson, Shohreh
Parker, Alexander
Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
title Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
title_full Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
title_fullStr Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
title_full_unstemmed Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
title_short Telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
title_sort telomere length in peripheral blood leukocytes and risk of renal cell carcinoma
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8798989/
https://www.ncbi.nlm.nih.gov/pubmed/35117117
http://dx.doi.org/10.21037/tcr.2019.06.36
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