Prognostic value of Livin in surgical specimen and biopsy in patients with osteosarcoma

BACKGROUND: Previous studies have shown that various apoptotic related factors were closely related to osteosarcoma (OS), and the correlation between apoptotic inhibitory protein Livin and OS has also been confirmed. Despite of the abundant surveys focusing on the effects of Livin positive expression on overall survival and metastasis of OS, the results were remained obscure. METHODS: A meta-analysis was conducted to explore the relationship of Livin expression in prognosis of OS. We searched CBM, Chinese VIP database, Wanfang database, CNKI, Springer, ISI Web of Knowledge, the Cochrane library, Embase and NCBI PubMed from the establishment to November 17, 2018 for the full retrieval of Livin positive expression and OS prognosis. We used Newcastle-Ottawa Scale (NOS) to evaluate the quality of enrolled studies. RESULTS: There were 10 studies involving 439 OS patients analyzed in this research. The results of meta-analysis revealed the meaningful association between positive expression of Livin and OS metastasis (OR =8.62, 95% CI: 4.08–18.21, P<0.0001), low 3-year survival rate with the pooled OR was 5.82 (95% CI: 3.34–10.13, P<0.0001). No significant publication bias or heterogeneity or were found in this meta-analysis. CONCLUSIONS: The results of the present study indicated that Livin expression was related to OS low 3-year survival rate and metastasis, which suggested that Livin may be a potential biomarker indicating poor prognosis of OS.